EN1 (gene)

Engrailed homeobox 1
Identifiers
Symbols	EN1;
External IDs	OMIM: 131290 MGI: 95389 HomoloGene: 50663 GeneCards: EN1 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleus Biological process • skeletal system development • multicellular organismal development • anatomical structure morphogenesis • dorsal/ventral pattern formation • proximal/distal pattern formation • midbrain development • hindbrain development • midbrain-hindbrain boundary development • embryonic forelimb morphogenesis • pigmentation • positive regulation of transcription from RNA polymerase II promoter • neuron development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2019	13798
Ensembl	ENSG00000163064	ENSMUSG00000058665
UniProt	Q05925	Q3USA2
RefSeq (mRNA)	NM_001426	NM_010133.2
RefSeq (protein)	NP_001417	NP_034263.2
Location (UCSC)	Chr 2: 119.6 – 119.61 Mb	Chr 1: 122.5 – 122.5 Mb
PubMed search	[1]	[2]

Homeobox protein engrailed-1 is a protein that in humans is encoded by the EN1 gene.

Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.

Further reading

• Logan C, Hanks MC, Noble-Topham S et al. (1993). "Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions". Dev. Genet. 13 (5): 345–358. doi:10.1002/dvg.1020130505. PMID 1363401. 
• Logan C, Willard HF, Rommens JM, Joyner AL (1989). "Chromosomal localization of the human homeo box-containing genes, EN1 and EN2". Genomics 4 (2): 206–209. doi:10.1016/0888-7543(89)90301-7. PMID 2567700. 
• Kozmik Z, Sure U, Rüedi D et al. (1995). "Deregulated expression of PAX5 in medulloblastoma". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5709–5713. doi:10.1073/pnas.92.12.5709. PMC 41766. PMID 7777574. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41766. 
• Loomis CA, Harris E, Michaud J et al. (1996). "The mouse Engrailed-1 gene and ventral limb patterning". Nature 382 (6589): 360–363. doi:10.1038/382360a0. PMID 8684466. 
• Joliot A, Trembleau A, Raposo G et al. (1997). "Association of Engrailed homeoproteins with vesicles presenting caveolae-like properties". Development 124 (10): 1865–75. PMID 9169834. 
• Mikkola I, Bruun JA, Holm T, Johansen T (2001). "Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins". J. Biol. Chem. 276 (6): 4109–4118. doi:10.1074/jbc.M008882200. PMID 11069920. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Schaefer LK, Wang S, Schaefer TS (2001). "Functional interaction of Jun and homeodomain proteins". J. Biol. Chem. 276 (46): 43074–43082. doi:10.1074/jbc.M102552200. PMID 11551904. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Hori Y, Gu X, Xie X, Kim SK (2006). "Differentiation of insulin-producing cells from human neural progenitor cells". PLoS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMC 1087208. PMID 15839736. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1087208. 
• Bachar-Dahan L, Goltzmann J, Yaniv A, Gazit A (2006). "Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway". Mol. Biol. Cell 17 (6): 2572–2580. doi:10.1091/mbc.E06-01-0052. PMC 1474795. PMID 16571670. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1474795. 
• Atit R, Sgaier SK, Mohamed OA et al. (2006). "Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse". Dev. Biol. 296 (1): 164–176. doi:10.1016/j.ydbio.2006.04.449. PMID 16730693. 

External links

• MeSH EN1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.