ZBTB7B

Zinc finger and BTB domain containing 7B
Identifiers
Symbols	ZBTB7B; DKFZp686G01254; THPOK; ZBTB15; ZFP67; ZNF857B; c-Krox; hcKrox
External IDs	OMIM: 607646 MGI: 102755 HomoloGene: 7605 GeneCards: ZBTB7B Gene
Gene Ontology Molecular function • DNA binding • zinc ion binding • metal ion binding Cellular component • intracellular • nucleus • nucleolus Biological process • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • multicellular organismal development • ectoderm development • cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51043	22724
Ensembl	ENSG00000160685	ENSMUSG00000028042
UniProt	O15156	Q5BJ24
RefSeq (mRNA)	NM_015872	NM_009565.4
RefSeq (protein)	NP_056956	NP_033591.2
Location (UCSC)	Chr 1: 154.98 – 154.99 Mb	Chr 3: 89.18 – 89.2 Mb
PubMed search	[1]	[2]

Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene.

ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g., COL1A1; MIM 120150) and has a role in development.[supplied by OMIM]

See also

• Zbtb7

Further reading

• Heegaard AM, Gehron Robey P, Vogel W et al. (1998). "Functional characterization of the human biglycan 5'-flanking DNA and binding of the transcription factor c-Krox". J. Bone Miner. Res. 12 (12): 2050–60. doi:10.1359/jbmr.1997.12.12.2050. PMID 9421237. 
• Ghayor C, Herrouin JF, Chadjichristos C et al. (2000). "Regulation of human COL2A1 gene expression in chondrocytes. Identification of C-Krox-responsive elements and modulation by phenotype alteration". J. Biol. Chem. 275 (35): 27421–38. doi:10.1074/jbc.M002139200. PMID 10856292. 
• Widom RL, Lee JY, Joseph C et al. (2002). "The hcKrox gene family regulates multiple extracellular matrix genes". Matrix Biol. 20 (7): 451–62. doi:10.1016/S0945-053X(01)00167-6. PMID 11691585. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
• Kypriotou M, Beauchef G, Chadjichristos C et al. (2007). "Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors". J. Biol. Chem. 282 (44): 32000–14. doi:10.1074/jbc.M705197200. PMID 17698844. 

External links

• MeSH ZBTB7B+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.