DLX5

Distal-less homeobox 5
PDB rendering based on 2djn.
Available structures PDB 2djn
Identifiers
Symbols	DLX5;
External IDs	OMIM: 600028 MGI: 101926 HomoloGene: 3825 GeneCards: DLX5 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding • transcription regulatory region DNA binding Cellular component • nucleus • nucleolus • cytoplasm Biological process • skeletal system development • osteoblast differentiation • endochondral ossification • multicellular organismal development • nervous system development • axon guidance • cell proliferation • embryonic limb morphogenesis • epithelial cell differentiation • inner ear morphogenesis • positive regulation of osteoblast differentiation • positive regulation of transcription, DNA-dependent • anatomical structure formation involved in morphogenesis • positive regulation of epithelial cell proliferation • positive regulation of canonical Wnt receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1749	13395
Ensembl	ENSG00000105880	ENSMUSG00000029755
UniProt	P56178	Q3TYA7
RefSeq (mRNA)	NM_005221	NM_010056
RefSeq (protein)	NP_005212	NP_034186
Location (UCSC)	Chr 7: 96.65 – 96.65 Mb	Chr 6: 6.83 – 6.83 Mb
PubMed search	[1]	[2]

Homeobox protein DLX-5 is a protein that in humans is encoded by the DLX5 gene.

Function

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less (Dll) gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.

Genetics

Mutations in the DLX5 gene have been shown to be involved in the hand and foot malformation syndrome.

Interactions

DLX5 has been shown to interact with DLX2, MSX1 and MSX2.

Further reading

• Bapat S, Galande S (2005). "Association by guilt: identification of DLX5 as a target for MeCP2 provides a molecular link between genomic imprinting and Rett syndrome.". Bioessays 27 (7): 676–80. doi:10.1002/bies.20266. PMID 15954098. 
• Scherer SW, Poorkaj P, Massa H, et al. (1995). "Physical mapping of the split hand/split foot locus on chromosome 7 and implication in syndromic ectrodactyly.". Hum. Mol. Genet. 3 (8): 1345–54. doi:10.1093/hmg/3.8.1345. PMID 7987313. 
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549. 
• Zhang H, Hu G, Wang H, et al. (1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism.". Mol. Cell. Biol. 17 (5): 2920–32. PMC 232144. PMID 9111364. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232144. 
• Newberry EP, Latifi T, Towler DA (1999). "The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter.". Biochemistry 38 (33): 10678–90. doi:10.1021/bi990967j. PMID 10451362. 
• Eisenstat DD, Liu JK, Mione M, et al. (1999). "DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation.". J. Comp. Neurol. 414 (2): 217–37. doi:10.1002/(SICI)1096-9861(19991115)414:2<217::AID-CNE6>3.0.CO;2-I. PMID 10516593. 
• Masuda Y, Sasaki A, Shibuya H, et al. (2001). "Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function.". J. Biol. Chem. 276 (7): 5331–8. doi:10.1074/jbc.M008590200. PMID 11084035. 
• Yu G, Zerucha T, Ekker M, Rubenstein JL (2002). "Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins.". Brain Res. Dev. Brain Res. 130 (2): 217–30. doi:10.1016/S0165-3806(01)00239-5. PMID 11675124. 
• Sasaki A, Masuda Y, Iwai K, et al. (2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851. 
• Willis DM, Loewy AP, Charlton-Kachigian N, et al. (2002). "Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex.". J. Biol. Chem. 277 (40): 37280–91. doi:10.1074/jbc.M206482200. PMID 12145306. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961. 
• Okita C, Meguro M, Hoshiya H, et al. (2004). "A new imprinted cluster on the human chromosome 7q21-q31, identified by human-mouse monochromosomal hybrids.". Genomics 81 (6): 556–9. doi:10.1016/S0888-7543(03)00052-1. PMID 12782124. 
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 

External links

• MeSH DLX5+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.