RFX1

Regulatory factor X, 1 (influences HLA class II expression)
PDB rendering based on 1dp7.
Available structures PDB 1dp7
Identifiers
Symbols	RFX1; EFC; RFX
External IDs	OMIM: 600006 MGI: 105982 HomoloGene: 2189 GeneCards: RFX1 Gene
Gene Ontology Molecular function • DNA binding • sequence-specific enhancer binding RNA polymerase II transcription factor activity • protein binding Cellular component • nucleus Biological process • regulation of transcription, DNA-dependent • immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5989	19724
Ensembl	ENSG00000132005	ENSMUSG00000031706
UniProt	P22670	Q3V383
RefSeq (mRNA)	NM_002918	NM_009055.4
RefSeq (protein)	NP_002909	NP_033081.3
Location (UCSC)	Chr 19: 14.07 – 14.12 Mb	Chr 8: 86.59 – 86.62 Mb
PubMed search	[1]	[2]

MHC class II regulatory factor RFX1 is a protein that in humans is encoded by the RFX1 gene.

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.

Interactions

RFX1 has been shown to interact with Abl gene.

Further reading

• Herrero Sanchez C, Reith W, Silacci P, Mach B (1992). "The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters.". Mol. Cell. Biol. 12 (9): 4076–83. PMC 360302. PMID 1508204. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=360302. 
• Reith W, Herrero-Sanchez C, Kobr M, et al. (1991). "MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain.". Genes Dev. 4 (9): 1528–40. doi:10.1101/gad.4.9.1528. PMID 2253877. 
• Sáfrány G, Perry RP (1993). "Transcription factor RFX1 helps control the promoter of the mouse ribosomal protein-encoding gene rpL30 by binding to its alpha element.". Gene 132 (2): 279–83. doi:10.1016/0378-1119(93)90208-K. PMID 8224874. 
• Siegrist CA, Durand B, Emery P, et al. (1993). "RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer.". Mol. Cell. Biol. 13 (10): 6375–84. PMC 364696. PMID 8413236. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=364696. 
• Emery P, Durand B, Mach B, Reith W (1996). "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom.". Nucleic Acids Res. 24 (5): 803–7. doi:10.1093/nar/24.5.803. PMC 145730. PMID 8600444. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=145730. 
• Doyle J, Hoffman S, Ucla C, et al. (1996). "Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.". Genomics 35 (1): 227–30. doi:10.1006/geno.1996.0343. PMID 8661125. 
• Agami R, Shaul Y (1998). "The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes.". Oncogene 16 (14): 1779–88. doi:10.1038/sj.onc.1201708. PMID 9583676. 
• Katan-Khaykovich Y, Shaul Y (1998). "RFX1, a single DNA-binding protein with a split dimerization domain, generates alternative complexes.". J. Biol. Chem. 273 (38): 24504–12. doi:10.1074/jbc.273.38.24504. PMID 9733744. 
• Iwama A, Pan J, Zhang P, et al. (1999). "Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.". Mol. Cell. Biol. 19 (6): 3940–50. PMC 104353. PMID 10330134. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=104353. 
• Zajac-Kaye M, Ben-Baruch N, Kastanos E, et al. (2000). "Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells.". Biochem. J.. 345 345 (3): 535–41. doi:10.1042/0264-6021:3450535. PMC 1220788. PMID 10642512. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220788. 
• Katan-Khaykovich Y, Shaul Y (2001). "Nuclear import and DNA-binding activity of RFX1. Evidence for an autoinhibitory mechanism.". Eur. J. Biochem. 268 (10): 3108–16. doi:10.1046/j.1432-1327.2001.02211.x. PMID 11358531. 
• Morotomi-Yano K, Yano K, Saito H, et al. (2002). "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.". J. Biol. Chem. 277 (1): 836–42. doi:10.1074/jbc.M108638200. PMID 11682486. 
• Sengupta PK, Fargo J, Smith BD (2002). "The RFX family interacts at the collagen (COL1A2) start site and represses transcription.". J. Biol. Chem. 277 (28): 24926–37. doi:10.1074/jbc.M111712200. PMID 11986307. 
• Nakayama A, Murakami H, Maeyama N, et al. (2003). "Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter.". J. Biol. Chem. 278 (1): 233–40. doi:10.1074/jbc.M209574200. PMID 12411430. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Norquay LD, Yang X, Sheppard P, et al. (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin.". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117. 
• Maijgren S, Sur I, Nilsson M, Toftgård R (2004). "Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.". Arch. Dermatol. Res. 295 (11): 482–9. doi:10.1007/s00403-004-0456-5. PMID 15024578. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446. 

External links

• MeSH RFX1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.