TEAD3

TEA domain family member 3
	; PDB rendering based on 2hzd.
Available structures
PDB	2hzd
Identifiers
Symbols	TEAD3; DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5
External IDs	OMIM: 603170 MGI: 109241 HomoloGene: 81821 GeneCards: TEAD3 Gene
Gene Ontology
Molecular function	• DNA binding; • sequence-specific DNA binding transcription factor activity; • protein binding;
Cellular component	• nucleus; • transcription factor complex;
Biological process	• transcription, DNA-dependent; • regulation of transcription, DNA-dependent; • regulation of transcription from RNA polymerase II promoter; • female pregnancy; • hippo signaling cascade; • positive regulation of transcription from RNA polymerase II promoter;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene.^[1]^[2]^[3]

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon.^[3]

[edit] References

^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Mar 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009.
^ Jacquemin P, Martial JA, Davidson I (Jun 1997). "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer". J Biol Chem 272 (20): 12928–37. doi:10.1074/jbc.272.20.12928. PMID 9148898.
^ ^a ^b "Entrez Gene: TEAD3 TEA domain family member 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7005.

[edit] Further reading

Jiang SW, Wu K, Eberhardt NL (1999). "Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer.". Mol. Endocrinol. 13 (6): 879–89. doi:10.1210/me.13.6.879. PMID 10379887.
Vaudin P, Delanoue R, Davidson I, et al. (1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.". Development 126 (21): 4807–16. PMID 10518497.
Vassilev A, Kaneko KJ, Shu H, et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.". Genes Dev. 15 (10): 1229–41. doi:10.1101/gad.888601. PMC 313800. PMID 11358867. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=313800.
Maeda T, Mazzulli JR, Farrance IK, Stewart AF (2002). "Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes.". J. Biol. Chem. 277 (27): 24346–52. doi:10.1074/jbc.M201171200. PMID 11986313.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Peng L, Huang Y, Jin F, et al. (2005). "Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1.". Mol. Endocrinol. 18 (8): 2049–60. doi:10.1210/me.2004-0028. PMID 15131259.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.

[edit] External links

MeSH TEAD3+protein,+human

This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it.

[pmid9889009-0] Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Mar 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009.

[pmid9148898-1] Jacquemin P, Martial JA, Davidson I (Jun 1997). "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer". J Biol Chem 272 (20): 12928–37. doi:10.1074/jbc.272.20.12928. PMID 9148898.

[entrez-2] "Entrez Gene: TEAD3 TEA domain family member 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7005.

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[2]

[3]

Nov	DEC	Jan
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2010	2011	2012

TEAD3

[edit] References

[edit] Further reading

[edit] External links

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