HOXC8

Homeobox C8
Identifiers
Symbols	HOXC8; HOX3; HOX3A
External IDs	OMIM: 142970 MGI: 96198 HomoloGene: 88803 GeneCards: HOXC8 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-dependent • regulation of transcription, DNA-dependent • multicellular organismal development • anterior/posterior pattern formation • neuron differentiation • skeletal system morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3224	15426
Ensembl	ENSG00000037965	ENSMUSG00000001657
UniProt	P31273	Q8BNV9
RefSeq (mRNA)	NM_022658	NM_010466.2
RefSeq (protein)	NP_073149	NP_034596.1
Location (UCSC)	Chr 12: 54.4 – 54.41 Mb	Chr 15: 102.82 – 102.82 Mb
PubMed search	[1]	[2]

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.

See also

• Homeobox

Interactions

HOXC8 has been shown to interact with Mothers against decapentaplegic homolog 6 and Mothers against decapentaplegic homolog 1.

Further reading

• Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=335308. 
• Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes". Genome 31 (2): 745–56. PMID 2576652. 
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1987). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104–8. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=387083. 
• Simeone A, Mavilio F, Acampora D, et al. (1987). "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4914–8. doi:10.1073/pnas.84.14.4914. PMC 305217. PMID 2885844. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305217. 
• Cannizzaro LA, Croce CM, Griffin CA, et al. (1987). "Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13". Am. J. Hum. Genet. 41 (1): 1–15. PMC 1684175. PMID 2886047. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1684175. 
• Lawrence HJ, Stage KM, Mathews CH, et al. (1993). "Expression of HOX C homeobox genes in lymphoid cells". Cell Growth Differ. 4 (8): 665–9. PMID 8104467. 
• Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877. 
• Flagiello D, Gibaud A, Dutrillaux B, et al. (1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Lett. 415 (3): 263–7. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979. 
• Shi X, Yang X, Chen D, et al. (1999). "Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling". J. Biol. Chem. 274 (19): 13711–7. doi:10.1074/jbc.274.19.13711. PMID 10224145. 
• Prévôt D, Voeltzel T, Birot AM, et al. (2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. doi:10.1074/jbc.275.1.147. PMID 10617598. 
• Bai S, Shi X, Yang X, Cao X (2000). "Smad6 as a transcriptional corepressor". J. Biol. Chem. 275 (12): 8267–70. doi:10.1074/jbc.275.12.8267. PMID 10722652. 
• Wan M, Shi X, Feng X, Cao X (2001). "Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression". J. Biol. Chem. 276 (13): 10119–25. doi:10.1074/jbc.M006918200. PMID 11139569. 
• Schaefer LK, Wang S, Schaefer TS (2001). "Functional interaction of Jun and homeodomain proteins". J. Biol. Chem. 276 (46): 43074–82. doi:10.1074/jbc.M102552200. PMID 11551904. 
• Waltregny D, Alami Y, Clausse N, et al. (2002). "Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation". Prostate 50 (3): 162–9. doi:10.1002/pros.10045. PMID 11813208. 
• Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Bayarsaihan D, Enkhmandakh B, Makeyev A, et al. (2003). "Homez, a homeobox leucine zipper gene specific to the vertebrate lineage". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10358–63. doi:10.1073/pnas.1834010100. PMC 193566. PMID 12925734. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=193566. 
• Luo L, Yang X, Takihara Y, et al. (2004). "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions". Nature 427 (6976): 749–53. doi:10.1038/nature02305. PMID 14973489. 

External links

• MeSH HOXC8+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.