JARID1D

Lysine (K)-specific demethylase 5D
Rendering based on PDB 2E6R.
Available structures PDB 2E6R, 2YQE
Identifiers
Symbols	KDM5D; HY; HYA; JARID1D; KIAA0234; SMCY
External IDs	OMIM: 426000 MGI: 99780 HomoloGene: 55838 GeneCards: KDM5D Gene
Gene Ontology Molecular function • molecular_function • DNA binding • protein binding • zinc ion binding • oxidoreductase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • metal ion binding Cellular component • cellular_component • intracellular • nucleus Biological process • spermatogenesis • chromatin modification Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8284	20592
Ensembl	ENSG00000012817	ENSMUSG00000056673
UniProt	Q9BY66	Q3URX5
RefSeq (mRNA)	NM_001146705.1	NM_011419.3
RefSeq (protein)	NP_001140177.1	NP_035549.1
Location (UCSC)	Chr Y: 21.87 – 21.91 Mb	Chr Y: 0.23 – 0.28 Mb
PubMed search	[1]	[2]

Lysine-specific demethylase 5D is an enzyme that in humans is encoded by the KDM5D gene.

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient.

Further reading

• Simpson E, Scott D, Chandler P (1997). "The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning.". Annu. Rev. Immunol. 15: 39–61. doi:10.1146/annurev.immunol.15.1.39. PMID 9143681. 
• Wolf U (1998). "The serologically detected H-Y antigen revisited.". Cytogenet. Cell Genet. 80 (1–4): 232–5. doi:10.1159/000014986. PMID 9678364. 
• Agulnik AI, Mitchell MJ, Lerner JL, et al. (1994). "A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.". Hum. Mol. Genet. 3 (6): 873–8. doi:10.1093/hmg/3.6.873. PMID 7524912. 
• Wang W, Meadows LR, den Haan JM, et al. (1995). "Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein.". Science 269 (5230): 1588–90. doi:10.1126/science.7667640. PMID 7667640. 
• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502. 
• Agulnik AI, Bishop CE, Lerner JL, et al. (1997). "Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.". Mamm. Genome 8 (2): 134–8. doi:10.1007/s003359900372. PMID 9060413. 
• Rufer N, Wolpert E, Helg C, et al. (1998). "HA-1 and the SMCY-derived peptide FIDSYICQV (H-Y) are immunodominant minor histocompatibility antigens after bone marrow transplantation.". Transplantation 66 (7): 910–6. doi:10.1097/00007890-199810150-00016. PMID 9798702. 
• Lau YF, Zhang J (2000). "Expression analysis of thirty one Y chromosome genes in human prostate cancer.". Mol. Carcinog. 27 (4): 308–21. doi:10.1002/(SICI)1098-2744(200004)27:4<308::AID-MC9>3.0.CO;2-R. PMID 10747295. 
• Shen P, Wang F, Underhill PA, et al. (2000). "Population genetic implications from sequence variation in four Y chromosome genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7354–9. doi:10.1073/pnas.97.13.7354. PMC 16549. PMID 10861003. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16549. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.". Nature 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422. 
• Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Miklos DB, Kim HT, Miller KH, et al. (2005). "Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission.". Blood 105 (7): 2973–8. doi:10.1182/blood-2004-09-3660. PMC 1350982. PMID 15613541. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1350982. 
• Piper KP, McLarnon A, Arrazi J, et al. (2007). "Functional HY-specific CD8+ T cells are found in a high proportion of women following pregnancy with a male fetus.". Biol. Reprod. 76 (1): 96–101. doi:10.1095/biolreprod.106.055426. PMID 16988213. 
• Iwase S, Lan F, Bayliss P, et al. (2007). "The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.". Cell 128 (6): 1077–88. doi:10.1016/j.cell.2007.02.017. PMID 17320160. 
• Lee MG, Norman J, Shilatifard A, Shiekhattar R (2007). "Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein.". Cell 128 (5): 877–87. doi:10.1016/j.cell.2007.02.004. PMID 17320162. 

External links

• MeSH JARID1D+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.