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From Wikipedia, the free encyclopedia
| Sp8 transcription factor | ||||||||
|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||
| Symbols | SP8; BTD | |||||||
| External IDs | OMIM: 608306 MGI: 2443471 HomoloGene: 18548 GeneCards: SP8 Gene | |||||||
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| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 221833 | 320145 | ||||||
| Ensembl | ENSG00000164651 | ENSMUSG00000048562 | ||||||
| UniProt | Q8IXZ3 | Q8BMJ | ||||||
| RefSeq (mRNA) | NM_182700.4 | NM_177082.4 | ||||||
| RefSeq (protein) | NP_874359.2 | NP_796056.2 | ||||||
| Location (UCSC) | Chr 7: 20.82 – 20.83 Mb |
Chr 12: 120.08 – 120.09 Mb |
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| PubMed search | [1] | [2] |
Transcription factor Sp8 also known as specificity protein 8 (SP-8) or Btd transcription factor (buttonhead)[1] is a protein that in humans is encoded by the SP8 gene.[2][3] Sp8 is a transcription factor in the Sp/KLF family.
[edit] Function
Sp8 mediates limb outgrowth during early development.[1] Sp8 deletion in mice resulted in severe exencephaly.[4]
[edit] References
- ^ a b Treichel D, Schöck F, Jäckle H, Gruss P, Mansouri A (November 2003). "mBtd is required to maintain signaling during murine limb development". Genes Dev. 17 (21): 2630–5. doi:10.1101/gad.274103. PMC 280612. PMID 14597661. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=280612.
- ^ Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ (October 2003). "Sp8 is crucial for limb outgrowth and neuropore closure". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12195–200. doi:10.1073/pnas.2134310100. PMC 218735. PMID 14526104. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=218735.
- ^ "Entrez Gene: Sp8 transcription factor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=221833.
- ^ Waclaw RR, Allen ZJ, Bell SM, Erdélyi F, Szabó G, Potter SS, Campbell K (February 2006). "The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons". Neuron 49 (4): 503–16. doi:10.1016/j.neuron.2006.01.018. PMID 16476661.
[edit] Further reading
- Lee MT, Chen CH, Lee CS, et al. (2011). "Genome-wide association study of bipolar I disorder in the Han Chinese population.". Mol. Psychiatry 16 (5): 548–56. doi:10.1038/mp.2010.43. PMID 20386566.
- Milona MA, Gough JE, Edgar AJ (2004). "Genomic structure and cloning of two transcript isoforms of human Sp8.". BMC Genomics 5: 86. doi:10.1186/1471-2164-5-86. PMID 15533246.
- Jugessur A, Shi M, Gjessing HK, et al. (2010). "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.". PLoS ONE 5 (7): e11493. doi:10.1371/journal.pone.0011493. PMC 2901336. PMID 20634891. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2901336.
- Barber MJ, Mangravite LM, Hyde CL, et al. (2010). "Genome-wide association of lipid-lowering response to statins in combined study populations.". PLoS ONE 5 (3): e9763. doi:10.1371/journal.pone.0009763. PMID 20339536.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
- Ravasi T, Suzuki H, Cannistraci CV, et al. (2010). "An atlas of combinatorial transcriptional regulation in mouse and man.". Cell 140 (5): 744–52. doi:10.1016/j.cell.2010.01.044. PMC 2836267. PMID 20211142. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2836267.
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