NFE2L3

Nuclear factor (erythroid-derived 2)-like 3
Identifiers
Symbols	NFE2L3; NRF3
External IDs	OMIM: 604135 MGI: 1339958 HomoloGene: 3168 GeneCards: NFE2L3 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • transcription coactivator activity • sequence-specific DNA binding • protein dimerization activity Cellular component • nucleus Biological process • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9603	18025
Ensembl	ENSG00000050344	ENSMUSG00000029832
UniProt	Q9Y4A8	Q9WTM4
RefSeq (mRNA)	NM_004289	NM_010903.1
RefSeq (protein)	NP_004280	NP_035033.1
Location (UCSC)	Chr 7: 26.19 – 26.23 Mb	Chr 6: 51.38 – 51.41 Mb
PubMed search	[1]	[2]

Nuclear factor erythroid 2-related factor 3, also known as NF-E2-related factor 3 or Nrf3, is a transcription factor that in humans is encoded by the NFE2L3 gene.

Function

This gene encodes a member of the cap 'n' collar basic-region leucine zipper (bZIP) family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors (MAF) to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope.

Further reading

• Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine.". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. 
• Sankaranarayanan K, Jaiswal AK (2004). "Nrf3 negatively regulates antioxidant-response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene.". J. Biol. Chem. 279 (49): 50810–7. doi:10.1074/jbc.M404984200. PMID 15385560. 
• Chénais B, Derjuga A, Massrieh W, et al. (2005). "Functional and placental expression analysis of the human NRF3 transcription factor.". Mol. Endocrinol. 19 (1): 125–37. doi:10.1210/me.2003-0379. PMID 15388789. 
• Nouhi Z, Chevillard G, Derjuga A, Blank V (2007). "Endoplasmic reticulum association and N-linked glycosylation of the human Nrf3 transcription factor.". FEBS Lett. 581 (28): 5401–6. doi:10.1016/j.febslet.2007.10.041. PMID 17976382. 
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Terui K, Takahashi Y, Kitazawa J, et al. (2000). "Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin.". Tohoku J. Exp. Med. 192 (4): 259–73. doi:10.1620/tjem.192.259. PMID 11286316. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1998. doi:10.1101/gr.8.11.1097. PMID 9847074. 
• Zhang Y, Kobayashi A, Yamamoto M, Hayes JD (2009). "The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence.". J. Biol. Chem. 284 (5): 3195–210. doi:10.1074/jbc.M805337200. PMID 19047052. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.