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From Wikipedia, the free encyclopedia
| Zinc finger protein 43 | ||||||||
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| Identifiers | ||||||||
| Symbols | ZNF43; DKFZp686L1854; HTF6; KOX27; ZNF39L1 | |||||||
| External IDs | OMIM: 603972 MGI: 3040691 HomoloGene: 86693 GeneCards: ZNF43 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 7594 | 238690 | ||||||
| Ensembl | ENSG00000198521 | ENSMUSG00000055480 | ||||||
| UniProt | P17038 | n/a | ||||||
| RefSeq (mRNA) | NM_003423 | NM_001001152.2 | ||||||
| RefSeq (protein) | NP_003414 | NP_001001152.1 | ||||||
| Location (UCSC) | Chr 19: 21.99 – 22.03 Mb |
Chr 13: 67.36 – 67.37 Mb |
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| PubMed search | [1] | [2] |
Zinc finger protein 43 is a protein that in humans is encoded by the ZNF43 gene.[1][2]
This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions.[2]
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[edit] See also
[edit] References
- ^ Lovering R, Trowsdale J (Jul 1991). "A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines". Nucleic Acids Res 19 (11): 2921–8. doi:10.1093/nar/19.11.2921. PMC 328252. PMID 1711675. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=328252.
- ^ a b "Entrez Gene: ZNF43 zinc finger protein 43". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7594.
[edit] Further reading
- Huebner K, Druck T, Croce CM, Thiesen HJ (1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". Am. J. Hum. Genet. 48 (4): 726–40. PMC 1682948. PMID 2014798. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1682948.
- Bellefroid EJ, Poncelet DA, Lecocq PJ et al. (1991). "The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3608–12. doi:10.1073/pnas.88.9.3608. PMC 51501. PMID 2023909. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=51501.
- Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–74. PMID 2288909.
- Bellefroid EJ, Marine JC, Ried T et al. (1993). "Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells". EMBO J. 12 (4): 1363–74. PMC 413348. PMID 8467795. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=413348.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
- Simpson JC, Wellenreuther R, Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Wiemann S, Arlt D, Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
- Mehrle A, Rosenfelder H, Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.
- Takahashi T, Furuchi T, Naganuma A (2007). "Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells". Cancer Res. 66 (24): 11932–7. doi:10.1158/0008-5472.CAN-06-3220. PMID 17178891.
[edit] External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it. |
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