POU3F2

POU class 3 homeobox 2
Identifiers
Symbols	POU3F2; BRN2; OCT7; OTF7; POUF3
External IDs	OMIM: 600494 MGI: 101895 HomoloGene: 4095 GeneCards: POU3F2 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • protein binding • identical protein binding • sequence-specific DNA binding Cellular component • nucleus • transcription factor complex Biological process • transcription, DNA-dependent • regulation of transcription, DNA-dependent • positive regulation of cell proliferation • epidermis development • astrocyte development • cerebral cortex radially oriented cell migration • forebrain ventricular zone progenitor cell division • hypothalamus cell differentiation • neurohypophysis development • myelination in peripheral nervous system • neuron differentiation • positive regulation of multicellular organism growth • regulation of cell differentiation • positive regulation of transcription from RNA polymerase II promoter • regulation of axonogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5454	18992
Ensembl	ENSG00000184486	ENSMUSG00000052621
UniProt	P20265	P31360
RefSeq (mRNA)	NM_005604	NM_008899.1
RefSeq (protein)	NP_005595	NP_032925.1
Location (UCSC)	Chr 6: 99.28 – 99.29 Mb	Chr 4: 22.41 – 22.42 Mb
PubMed search	[1]	[2]

POU domain, class 3, transcription factor 2 is a protein that in humans is encoded by the POU3F2 gene.

N-Oct-3 is a protein belonging to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, which occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176), and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression.[supplied by OMIM]

Interactions

POU3F2 has been shown to interact with PQBP1.

See also

• Octamer transcription factor

Further reading

• Hara Y, Rovescalli AC, Kim Y, Nirenberg M (1992). "Structure and evolution of four POU domain genes expressed in mouse brain.". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3280–4. doi:10.1073/pnas.89.8.3280. PMC 48850. PMID 1565620. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=48850. 
• Schreiber E, Harshman K, Kemler I, et al. (1990). "Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins.". Nucleic Acids Res. 18 (18): 5495–503. doi:10.1093/nar/18.18.5495. PMC 332229. PMID 2216722. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=332229. 
• He X, Treacy MN, Simmons DM, et al. (1989). "Expression of a large family of POU-domain regulatory genes in mammalian brain development.". Nature 340 (6228): 35–41. doi:10.1038/340035a0. PMID 2739723. 
• Eisen T, Easty DJ, Bennett DC, Goding CR (1995). "The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression.". Oncogene 11 (10): 2157–64. PMID 7478537. 
• Atanasoski S, Toldo SS, Malipiero U, et al. (1995). "Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16.". Genomics 26 (2): 272–80. doi:10.1016/0888-7543(95)80211-4. PMID 7601453. 
• Thomson JA, Murphy K, Baker E, et al. (1995). "The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells.". Oncogene 11 (4): 691–700. PMID 7651733. 
• Atanasoski S, Schreiber E, Fontana A, Herr W (1997). "N-Oct 5 is generated by in vitro proteolysis of the neural POU-domain protein N-Oct 3.". Oncogene 14 (11): 1287–94. doi:10.1038/sj.onc.1200953. PMID 9178889. 
• Petersenn S, Rasch AC, Heyens M, Schulte HM (1998). "Structure and regulation of the human growth hormone-releasing hormone receptor gene.". Mol. Endocrinol. 12 (2): 233–47. doi:10.1210/me.12.2.233. PMID 9482665. 
• Kuhlbrodt K, Herbarth B, Sock E, et al. (1998). "Cooperative function of POU proteins and SOX proteins in glial cells.". J. Biol. Chem. 273 (26): 16050–7. doi:10.1074/jbc.273.26.16050. PMID 9632656. 
• Waragai M, Lammers CH, Takeuchi S, et al. (1999). "PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival.". Hum. Mol. Genet. 8 (6): 977–87. doi:10.1093/hmg/8.6.977. PMID 10332029. 
• Smit DJ, Smith AG, Parsons PG, et al. (2000). "Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors.". Eur. J. Biochem. 267 (21): 6413–22. doi:10.1046/j.1432-1327.2000.01737.x. PMID 11029584. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Jaegle M, Ghazvini M, Mandemakers W, et al. (2003). "The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development.". Genes Dev. 17 (11): 1380–91. doi:10.1101/gad.258203. PMC 196070. PMID 12782656. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=196070. 
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Goodall J, Martinozzi S, Dexter TJ, et al. (2004). "Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin.". Mol. Cell. Biol. 24 (7): 2915–22. doi:10.1128/MCB.24.7.2915-2922.2004. PMC 371132. PMID 15024079. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=371132. 
• Goodall J, Wellbrock C, Dexter TJ, et al. (2004). "The Brn-2 transcription factor links activated BRAF to melanoma proliferation.". Mol. Cell. Biol. 24 (7): 2923–31. doi:10.1128/MCB.24.7.2923-2931.2004. PMC 371133. PMID 15024080. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=371133. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Cobrinik D, Francis RO, Abramson DH, Lee TC (2007). "Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells.". Mol. Cancer 5 (1): 72. doi:10.1186/1476-4598-5-72. PMC 1764425. PMID 17163992. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1764425. 

External links

• MeSH POU3F2+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.