FOXP4

Forkhead box P4
Identifiers
Symbols	FOXP4; FLJ40908; FLJ44184; hFKHLA
External IDs	OMIM: 608924 MGI: 1921373 HomoloGene: 12536 GeneCards: FOXP4 Gene
Gene Ontology Molecular function • chromatin binding • double-stranded DNA binding • sequence-specific enhancer binding RNA polymerase II transcription factor activity • transcription factor binding • zinc ion binding • DNA bending activity • protein homodimerization activity • sequence-specific DNA binding • metal ion binding • protein heterodimerization activity Cellular component • intracellular • nucleus • transcription factor complex • cytoplasm Biological process • pattern specification process • heart development • tissue development • embryonic foregut morphogenesis • regulation of sequence-specific DNA binding transcription factor activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116113	74123
Ensembl	ENSG00000137166	ENSMUSG00000023991
UniProt	Q8IVH2	Q9DBY0
RefSeq (mRNA)	NM_001012426.1	NM_028767
RefSeq (protein)	NP_001012426.1	NP_083043
Location (UCSC)	Chr 6: 41.51 – 41.57 Mb	Chr 17: 48 – 48.06 Mb
PubMed search	[1]	[2]

Forkhead box protein P4 is a protein that in humans is encoded by the FOXP4 gene.

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.

Further reading

• Katoh M, Katoh M (2005). "Human FOX gene family (Review)". Int. J. Oncol. 25 (5): 1495–500. PMID 15492844. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Lu MM, Li S, Yang H, Morrisey EE (2003). "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Gene Expr. Patterns 2 (3–4): 223–8. doi:10.1016/S1567-133X(02)00058-3. PMID 12617805. 
• Teufel A, Wong EA, Mukhopadhyay M et al. (2003). "FoxP4, a novel forkhead transcription factor". Biochim. Biophys. Acta 1627 (2–3): 147–52. doi:10.1016/S0167-4781(03)00074-5. PMID 12818433. 
• Lu MM, Li S, Yang H, Morrisey EE (2002). "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Mech. Dev. 119 Suppl 1: S197–202. doi:10.1016/S0925-4773(03)00116-3. PMID 14516685. 
• Li S, Weidenfeld J, Morrisey EE (2004). "Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions". Mol. Cell. Biol. 24 (2): 809–22. doi:10.1128/MCB.24.2.809-822.2004. PMC 343786. PMID 14701752. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=343786. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Hannenhalli S, Putt ME, Gilmore JM et al. (2006). "Transcriptional genomics associates FOX transcription factors with human heart failure". Circulation 114 (12): 1269–76. doi:10.1161/CIRCULATIONAHA.106.632430. PMID 16952980.