ARID1B

AT rich interactive domain 1B (SWI1-like)
PDB rendering based on 2cxy.
Available structures PDB 2CXY, 2EH9
Identifiers
Symbols	ARID1B; 6A3-5; BAF250B; BRIGHT; DAN15; ELD/OSA1; KIAA1235; OSA2; P250R
External IDs	MGI: 1926129 HomoloGene: 32344 GeneCards: ARID1B Gene
Gene Ontology Molecular function • DNA binding • transcription coactivator activity • protein binding Cellular component • intracellular • nucleus • nucleolus • SWI/SNF complex • intracellular membrane-bounded organelle Biological process • regulation of transcription, DNA-dependent • nervous system development • chromatin modification • chromatin-mediated maintenance of transcription Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57492	239985
Ensembl	ENSG00000049618	ENSMUSG00000069729
UniProt	Q8NFD5	n/a
RefSeq (mRNA)	NM_017519.2	NM_001085355.1
RefSeq (protein)	NP_059989.2	NP_001078824.1
Location (UCSC)	Chr 6: 157.1 – 157.53 Mb	Chr 17: 4.99 – 5.35 Mb
PubMed search	[1]	[2]

AT-rich interactive domain-containing protein 1B is a protein that in humans is encoded by the ARID1B gene.

Interactions

ARID1B has been shown to interact with SMARCA4 and SMARCA2.

Further reading

• Martens JA, Winston F (2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes". Curr. Opin. Genet. Dev. 13 (2): 136–42. doi:10.1016/S0959-437X(03)00022-4. PMID 12672490. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Imbert G, Saudou F, Yvert G, et al. (1996). "Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats". Nat. Genet. 14 (3): 285–91. doi:10.1038/ng1196-285. PMID 8896557. 
• Mangel L, Ternes T, Schmitz B, Doerfler W (1998). "New 5'-(CGG)n-3' repeats in the human genome". J. Biol. Chem. 273 (46): 30466–71. doi:10.1074/jbc.273.46.30466. PMID 9804814. 
• Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits". Mol. Cell 3 (2): 247–53. doi:10.1016/S1097-2765(00)80315-9. PMID 10078207. 
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462. 
• Xue Y, Canman JC, Lee CS, et al. (2001). "The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13015–20. doi:10.1073/pnas.240208597. PMC 27170. PMID 11078522. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=27170. 
• Kato H, Tjernberg A, Zhang W, et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". J. Biol. Chem. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557. 
• Hurlstone AF, Olave IA, Barker N, et al. (2002). "Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein". Biochem. J. 364 (Pt 1): 255–64. PMC 1222568. PMID 11988099. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222568. 
• Inoue H, Furukawa T, Giannakopoulos S, et al. (2003). "Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors". J. Biol. Chem. 277 (44): 41674–85. doi:10.1074/jbc.M205961200. PMID 12200431. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Nie Z, Yan Z, Chen EH, et al. (2003). "Novel SWI/SNF Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23.8.2942-2952.2003. PMC 152562. PMID 12665591. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=152562. 
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
• Garin G, Badid C, McGregor B, et al. (2004). "Ischemia Induces Early Expression of a New Transcription Factor (6A3-5) in Kidney Vascular Smooth Muscle Cells : Studies in Rat and Human Renal Pathology". Am. J. Pathol. 163 (6): 2485–94. doi:10.1016/S0002-9440(10)63603-6. PMC 1892391. PMID 14633620. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1892391. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. 
• Wilsker D, Patsialou A, Zumbrun SD, et al. (2004). "The DNA-binding properties of the ARID-containing subunits of yeast and mammalian SWI/SNF complexes". Nucleic Acids Res. 32 (4): 1345–53. doi:10.1093/nar/gkh277. PMC 390273. PMID 14982958. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=390273. 
• Wang X, Nagl NG, Wilsker D, et al. (2005). "Two related ARID family proteins are alternative subunits of human SWI/SNF complexes". Biochem. J. 383 (Pt 2): 319–25. doi:10.1042/BJ20040524. PMC 1134073. PMID 15170388. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1134073. 
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148. 

External links

• MeSH ARID1B+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.