FOXH1

Forkhead box H1
Identifiers
Symbols	FOXH1; FAST-1; FAST1
External IDs	OMIM: 603621 MGI: 1347465 HomoloGene: 2914 GeneCards: FOXH1 Gene
Gene Ontology Molecular function • DNA binding • double-stranded DNA binding • sequence-specific DNA binding transcription factor activity • sequence-specific enhancer binding RNA polymerase II transcription factor activity • protein binding • transcription factor binding • DNA bending activity • protein domain specific binding • sequence-specific DNA binding • R-SMAD binding Cellular component • nucleus • transcription factor complex • activin responsive factor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • blood vessel development • heart looping • heart jogging • transcription, DNA-dependent • transforming growth factor beta receptor signaling pathway • transforming growth factor beta receptor signaling pathway • determination of left/right symmetry • specification of organ position • floor plate formation • embryonic heart tube anterior/posterior pattern formation • cell migration involved in gastrulation • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • axial mesoderm development • regulation of sequence-specific DNA binding transcription factor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8928	14106
Ensembl	ENSG00000160973	ENSMUSG00000033837
UniProt	O75593	Q0VEP8
RefSeq (mRNA)	NM_003923	NM_007989.3
RefSeq (protein)	NP_003914	NP_032015.1
Location (UCSC)	Chr 8: 145.7 – 145.7 Mb	Chr 15: 76.5 – 76.5 Mb
PubMed search	[1]	[2]

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.

See also

• FOX proteins

Interactions

FOXH1 has been shown to interact with DRAP1 and Mothers against decapentaplegic homolog 2.

Further reading

• Chen X, Weisberg E, Fridmacher V, et al. (1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature 389 (6646): 85–9. doi:10.1038/38008. PMID 9288972. 
• Liu F, Pouponnot C, Massagué J (1998). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. 11 (23): 3157–67. doi:10.1101/gad.11.23.3157. PMC 316747. PMID 9389648. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316747. 
• Liu B, Dou CL, Prabhu L, Lai E (1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. 19 (1): 424–30. PMC 83900. PMID 9858566. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=83900. 
• Dou C, Lee J, Liu B, et al. (2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86095. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Pessah M, Prunier C, Marais J, et al. (2001). "c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6198–203. doi:10.1073/pnas.101579798. PMC 33445. PMID 11371641. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=33445. 
• Iratni R, Yan YT, Chen C, et al. (2003). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Seoane J, Le HV, Shen L, et al. (2004). "Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation". Cell 117 (2): 211–23. doi:10.1016/S0092-8674(04)00298-3. PMID 15084259. 
• von Both I, Silvestri C, Erdemir T, et al. (2004). "Foxh1 is essential for development of the anterior heart field". Dev. Cell 7 (3): 331–45. doi:10.1016/j.devcel.2004.07.023. PMID 15363409. 
• Kelemen SF, Eisen HJ, Autieri MV (2005). "Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells". J. Heart Lung Transplant. 24 (3): 246–50. doi:10.1016/j.healun.2004.01.015. PMID 15737749. 
• Cui Q, Lim SK, Zhao B, Hoffmann FM (2005). "Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP". Oncogene 24 (24): 3864–74. doi:10.1038/sj.onc.1208556. PMID 15750622. 
• Hart AH, Willson TA, Wong M, et al. (2005). "Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1". Biochem. Biophys. Res. Commun. 333 (4): 1361–9. doi:10.1016/j.bbrc.2005.06.044. PMID 15982639. 
• Chen G, Nomura M, Morinaga H, et al. (2006). "Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor". J. Biol. Chem. 280 (43): 36355–63. doi:10.1074/jbc.M506147200. PMID 16120611. 

External links

• MeSH FOXH1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.