ZNF148

Zinc finger protein 148
Identifiers
Symbols	ZNF148; BERF-1; BFCOL1; DKFZp686L18248; HT-BETA; ZBP-89; ZFP148; pHZ-52
External IDs	OMIM: 601897 MGI: 1332234 HomoloGene: 8003 GeneCards: ZNF148 Gene
Gene Ontology
Molecular function	• double-stranded DNA binding; • sequence-specific DNA binding transcription factor activity; • protein binding; • zinc ion binding; • sequence-specific DNA binding; • metal ion binding;
Cellular component	• intracellular; • nucleus; • nucleolus; • Golgi apparatus;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • transcription from RNA polymerase II promoter; • protein complex assembly; • cellular defense response; • gamete generation; • negative regulation of gene expression; • negative regulation of transcription, DNA-dependent; • positive regulation of transcription from RNA polymerase II promoter;
	Sources: Amigo / QuickGO
Orthologs

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Zinc finger protein 148 is a protein that in humans is encoded by the ZNF148 gene.^[1]^[2]^[3]

[edit] Interactions

ZNF148 has been shown to interact with PTRF^[4] and P53.^[5]

[edit] See also

Zinc finger

[edit] References

^ Tommerup N, Vissing H (Nov 1995). "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders". Genomics 27 (2): 259–64. doi:10.1006/geno.1995.1040. PMID 7557990.
^ Antona V, Cammarata G, De Gregorio L, Dragani TA, Giallongo A, Feo S (Mar 1999). "The gene encoding the transcriptional repressor BERF-1 maps to a region of conserved synteny on mouse chromosome 16 and human chromosome 3 and a related pseudogene maps to mouse chromosome 8". Cytogenet Cell Genet 83 (1-2): 90–2. doi:10.1159/000015138. PMID 9925940.
^ "Entrez Gene: ZNF148 zinc finger protein 148". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7707.
^ Hasegawa, T; Takeuchi A, Miyaishi O, Xiao H, Mao J, Isobe K (Apr. 2000). "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters". Biochem. J. (ENGLAND) 347 Pt 1: 55–9. doi:10.1042/0264-6021:3470055. ISSN 0264-6021. PMC 1220930. PMID 10727401. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220930.
^ Bai, L; Merchant J L (Jul. 2001). "ZBP-89 promotes growth arrest through stabilization of p53". Mol. Cell. Biol. (United States) 21 (14): 4670–83. doi:10.1128/MCB.21.14.4670-4683.2001. ISSN 0270-7306. PMC 87140. PMID 11416144. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87140.

[edit] Further reading

Wang Y, Kobori JA, Hood L (1993). "The ht beta gene encodes a novel CACCC box-binding protein that regulates T-cell receptor gene expression.". Mol. Cell. Biol. 13 (9): 5691–701. PMC 360303. PMID 8355710. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=360303.
Merchant JL, Iyer GR, Taylor BR, et al. (1997). "ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter.". Mol. Cell. Biol. 16 (12): 6644–53. PMC 231666. PMID 8943318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231666.
Taniuchi T, Mortensen ER, Ferguson A, et al. (1997). "Overexpression of ZBP-89, a zinc finger DNA binding protein, in gastric cancer.". Biochem. Biophys. Res. Commun. 233 (1): 154–60. doi:10.1006/bbrc.1997.6310. PMID 9144414.
Law DJ, Tarlé SA, Merchant JL (1998). "The human ZBP-89 homolog, located at chromosome 3q21, represses gastrin gene expression.". Mamm. Genome 9 (2): 165–7. doi:10.1007/s003359900711. PMID 9457682.
Law GL, Itoh H, Law DJ, et al. (1998). "Transcription factor ZBP-89 regulates the activity of the ornithine decarboxylase promoter.". J. Biol. Chem. 273 (32): 19955–64. doi:10.1074/jbc.273.32.19955. PMID 9685330.
Ye S, Whatling C, Watkins H, Henney A (1999). "Human stromelysin gene promoter activity is modulated by transcription factor ZBP-89.". FEBS Lett. 450 (3): 268–72. doi:10.1016/S0014-5793(99)00509-8. PMID 10359087.
Hasegawa T, Takeuchi A, Miyaishi O, et al. (2000). "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters.". Biochem. J. 347 Pt 1: 55–9. doi:10.1042/0264-6021:3470055. PMC 1220930. PMID 10727401. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220930.
Bai L, Merchant JL (2000). "Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells.". J. Biol. Chem. 275 (39): 30725–33. doi:10.1074/jbc.M004249200. PMID 10899165.
Bai L, Merchant JL (2001). "ZBP-89 promotes growth arrest through stabilization of p53.". Mol. Cell. Biol. 21 (14): 4670–83. doi:10.1128/MCB.21.14.4670-4683.2001. PMC 87140. PMID 11416144. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87140.
Park H, Shelley CS, Arnaout MA (2003). "The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene.". Blood 101 (3): 894–902. doi:10.1182/blood-2002-03-0680. PMID 12393719.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Chen GG, Merchant JL, Lai PB, et al. (2003). "Mutation of p53 in recurrent hepatocellular carcinoma and its association with the expression of ZBP-89.". Am. J. Pathol. 162 (6): 1823–9. PMC 1868140. PMID 12759240. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1868140.
Wu Y, Diab I, Zhang X, et al. (2004). "Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89.". Oncogene 23 (1): 168–78. doi:10.1038/sj.onc.1207003. PMID 14712222.
Bai L, Yoon SO, King PD, Merchant JL (2005). "ZBP-89-induced apoptosis is p53-independent and requires JNK.". Cell Death Differ. 11 (6): 663–73. doi:10.1038/sj.cdd.4401393. PMID 14963412.
Samuelsson L, Stiller C, Friberg C, et al. (2004). "Association analysis of cystatin A and zinc finger protein 148, two genes located at the psoriasis susceptibility locus PSORS5.". J. Invest. Dermatol. 122 (6): 1399–400. doi:10.1046/j.0022-202X.2004.12604.x. PMID 15175029.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.

[edit] External links

MeSH ZNF148+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This protein-related article is a stub. You can help Wikipedia by expanding it.

[pmid7557990-0] Tommerup N, Vissing H (Nov 1995). "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders". Genomics 27 (2): 259–64. doi:10.1006/geno.1995.1040. PMID 7557990.

[pmid9925940-1] Antona V, Cammarata G, De Gregorio L, Dragani TA, Giallongo A, Feo S (Mar 1999). "The gene encoding the transcriptional repressor BERF-1 maps to a region of conserved synteny on mouse chromosome 16 and human chromosome 3 and a related pseudogene maps to mouse chromosome 8". Cytogenet Cell Genet 83 (1-2): 90–2. doi:10.1159/000015138. PMID 9925940.

[entrez-2] "Entrez Gene: ZNF148 zinc finger protein 148". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7707.

[pmid10727401-3] Hasegawa, T; Takeuchi A, Miyaishi O, Xiao H, Mao J, Isobe K (Apr. 2000). "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters". Biochem. J. (ENGLAND) 347 Pt 1: 55–9. doi:10.1042/0264-6021:3470055. ISSN 0264-6021. PMC 1220930. PMID 10727401. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220930.

[pmid11416144-4] Bai, L; Merchant J L (Jul. 2001). "ZBP-89 promotes growth arrest through stabilization of p53". Mol. Cell. Biol. (United States) 21 (14): 4670–83. doi:10.1128/MCB.21.14.4670-4683.2001. ISSN 0270-7306. PMC 87140. PMID 11416144. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87140.

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Nov	DEC	Jan
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2010	2011	2012

ZNF148

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[edit] Interactions

[edit] See also

[edit] References

[edit] Further reading

[edit] External links

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