NFIB (gene)

Nuclear factor I/B
Identifiers
Symbols	NFIB; HMGIC/NFIB; NFI-RED; NFIB2; NFIB3
External IDs	OMIM: 600728 MGI: 103188 HomoloGene: 4087 GeneCards: NFIB Gene
Gene Ontology Molecular function • DNA binding • double-stranded DNA binding • sequence-specific DNA binding transcription factor activity Cellular component • intracellular • nucleus • nucleolus Biological process • DNA replication • transcription, DNA-dependent • regulation of transcription, DNA-dependent • negative regulation of cell proliferation • lung development • forebrain development • hindbrain development • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4781	18028
Ensembl	ENSG00000147862	ENSMUSG00000008575
UniProt	O00712	Q3UFE1
RefSeq (mRNA)	NM_001190737.1	NM_008687
RefSeq (protein)	NP_001177666.1	NP_032713
Location (UCSC)	Chr 9: 14.08 – 14.4 Mb	Chr 4: 81.77 – 81.98 Mb
PubMed search	[1]	[2]

Nuclear factor 1 B-type is a protein that in humans is encoded by the NFIB gene.

Further reading

• Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing.". J. Biol. Chem. 272 (16): 10739–45. doi:10.1074/jbc.272.16.10739. PMID 9099724. 
• Geurts JM, Schoenmakers EF, Röijer E et al. (1998). "Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas". Oncogene 16 (7): 865–72. doi:10.1038/sj.onc.1201609. PMID 9484777. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Norquay LD, Yang X, Sheppard P et al. (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117. 
• Sheeter D, Du P, Rought S et al. (2003). "Surface CD4 expression modulated by a cellular factor induced by HIV type 1 infection". AIDS Res. Hum. Retroviruses 19 (2): 117–23. doi:10.1089/088922203762688621. PMID 12639247. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Mukhopadhyay SS, Rosen JM (2007). "The C-terminal domain of the Nuclear Factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells". Biochem. Biophys. Res. Commun. 358 (3): 770–6. doi:10.1016/j.bbrc.2007.04.185. PMC 1942171. PMID 17511965. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1942171. 

External links

• MeSH NFIB+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.