NEUROG2

Neurogenin 2
Identifiers
Symbols	NEUROG2; Atoh4; MGC46562; Math4A; NGN2; bHLHa8; ngn-2
External IDs	OMIM: 606624 MGI: 109619 HomoloGene: 7633 GeneCards: NEUROG2 Gene
Gene Ontology Molecular function • sequence-specific DNA binding • E-box binding Cellular component • nucleus Biological process • neuron migration • regulation of transcription, DNA-dependent • multicellular organismal development • axon guidance • central nervous system neuron development • neurogenesis • neuron differentiation • forebrain development • cell fate commitment • positive regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	63973	11924
Ensembl	ENSG00000178403	ENSMUSG00000027967
UniProt	Q9H2A3	P70447
RefSeq (mRNA)	NM_024019	NM_009718.2
RefSeq (protein)	NP_076924	NP_033848.1
Location (UCSC)	Chr 4: 113.43 – 113.44 Mb	Chr 3: 127.34 – 127.34 Mb
PubMed search	[1]	[2]

Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.

Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.

Further reading

• Gradwohl G, Fode C, Guillemot F (1996). "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors.". Dev. Biol. 180 (1): 227–41. doi:10.1006/dbio.1996.0297. PMID 8948587. 
• Simmons AD, Horton S, Abney AL, Johnson JE (2001). "Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers.". Dev. Biol. 229 (2): 327–39. doi:10.1006/dbio.2000.9984. PMID 11203697. 
• Kumar M, Bagchi B, Gupta SK, et al. (2007). "Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells.". Stem Cells Dev. 16 (4): 667–81. doi:10.1089/scd.2006.0115. PMID 17784840. 
• Deng S, Deng H, Le W, et al. (2009). "Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease.". Neurosci. Lett. 468 (3): HASH(0x24e91e0). doi:10.1016/j.neulet.2009.10.078. PMID 19879328. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Park CH, Kang JS, Yoon EH, et al. (2008). "Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro". FEBS Lett. 582 (5): 537–42. doi:10.1016/j.febslet.2008.01.018. PMID 18242186. 
• Fode C, Gradwohl G, Morin X, et al. (1998). "The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons". Neuron 20 (3): 483–94. doi:10.1016/S0896-6273(00)80989-7. PMID 9539123.