FOXP1

Forkhead box P1
Identifiers
Symbols	FOXP1; 12CC4; FLJ23741; MGC12942; MGC88572; MGC99551; QRF1; hFKH1B
External IDs	OMIM: 605515 MGI: 1914004 HomoloGene: 13092 GeneCards: FOXP1 Gene
Gene Ontology Molecular function • chromatin binding • double-stranded DNA binding • sequence-specific enhancer binding RNA polymerase II transcription factor activity • transcription factor binding • zinc ion binding • DNA bending activity • protein homodimerization activity • sequence-specific DNA binding • metal ion binding • protein heterodimerization activity Cellular component • intracellular • nucleus • transcription factor complex • nucleolus • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • positive regulation of mesenchymal cell proliferation • pre-B cell differentiation • positive regulation of immunoglobulin production • pattern specification process • heart development • skeletal muscle tissue development • embryo development • lung development • immunoglobulin V(D)J recombination • negative regulation of transcription, DNA-dependent • smooth muscle tissue development • regulation of sequence-specific DNA binding transcription factor activity • cardiac muscle cell differentiation • positive regulation of epithelial cell proliferation involved in lung morphogenesis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27086	108655
Ensembl	ENSG00000114861	ENSMUSG00000030067
UniProt	Q9H334	Q6P221
RefSeq (mRNA)	NM_001012505.1	NM_053202
RefSeq (protein)	NP_001012523.1	NP_444432
Location (UCSC)	Chr 3: 71 – 71.63 Mb	Chr 6: 98.88 – 99.22 Mb
PubMed search	[1]	[2]

FOXP1 ("forkhead box P1") is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors.

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.

It was shown that the embryonic stem cell (ESC)-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells. These results reveal a pivotal role for an Alternative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs (2).

See also

• FOXP2
• FOXP3
• FOX proteins
• Transcription factors

References

2 Mathieu Gabut, Payman Samavarchi-Tehrani, Xinchen Wang, Valentina Slobodeniuc, Dave O'Hanlon, Hoon-Ki Sung, Manuel Alvarez, Shaheynoor Talukder, Qun Pan, Esteban O. Mazzoni, Stephane Nedelec, Hynek Wichterle, Knut Woltjen, Timothy R. Hughes, Peter W. Zandstra, Andras Nagy, Jeffrey L. Wrana, and Benjamin J. Blencowe.An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming. Cell, 2011; DOI: 10.1016/j.cell.2011.08.023

Further reading

• Katoh M, Katoh M (2005). "Human FOX gene family (Review).". Int. J. Oncol. 25 (5): 1495–500. PMID 15492844. 
• Li C, Tucker PW (1994). "DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain.". Proc. Natl. Acad. Sci. U.S.A. 90 (24): 11583–7. doi:10.1073/pnas.90.24.11583. PMC 48028. PMID 8265594. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=48028. 
• Zhang QH, Ye M, Wu XY, (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934. 
• Banham AH, Beasley N, Campo E, (2002). "The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p". Cancer Res. 61 (24): 8820–9. PMID 11751404. 
• Wolska MK, Bukowski K, Jakubczak A (2002). "[Occurrence of beta-lactamase type ESBL and IBL in Pseudomonas aeruginosa rods]". Medycyna doświadczalna i mikrobiologia 53 (1): 45–51. PMID 11757404. 
• Strausberg RL, Feingold EA, Grouse LH, (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Wang B, Lin D, Li C, Tucker P (2003). "Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors". J. Biol. Chem. 278 (27): 24259–68. doi:10.1074/jbc.M207174200. PMID 12692134. 
• Li S, Weidenfeld J, Morrisey EE (2004). "Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions". Mol. Cell. Biol. 24 (2): 809–22. doi:10.1128/MCB.24.2.809-822.2004. PMC 343786. PMID 14701752. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=343786. 
• Ota T, Suzuki Y, Nishikawa T, (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Teramitsu I, Kudo LC, London SE, (2004). "Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction". J. Neurosci. 24 (13): 3152–63. doi:10.1523/JNEUROSCI.5589-03.2004. PMID 15056695. 
• Fox SB, Brown P, Han C, (2004). "Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas". Clin. Cancer Res. 10 (10): 3521–7. doi:10.1158/1078-0432.CCR-03-0461. PMID 15161711. 
• Shi C, Zhang X, Chen Z, (2004). "Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1". J. Clin. Invest. 114 (3): 408–18. doi:10.1172/JCI200421100. PMC 484980. PMID 15286807. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=484980. 
• Streubel B, Vinatzer U, Lamprecht A, (2005). "T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma". Leukemia 19 (4): 652–8. doi:10.1038/sj.leu.2403644. PMID 15703784. 
• Banham AH, Connors JM, Brown PJ, (2005). "Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma". Clin. Cancer Res. 11 (3): 1065–72. PMID 15709173. 
• Brown P, Marafioti T, Kusec R, Banham AH (2007). "The FOXP1 transcription factor is expressed in the majority of follicular lymphomas but is rarely expressed in classical and lymphocyte predominant Hodgkin's lymphoma". J. Mol. Histol. 36 (4): 249–56. doi:10.1007/s10735-005-6521-3. PMID 16200457. 
• Giatromanolaki A, Koukourakis MI, Sivridis E, (2006). "Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression". Mod. Pathol. 19 (1): 9–16. doi:10.1038/modpathol.3800494. PMID 16258506. 
• Sagaert X, de Paepe P, Libbrecht L, (2006). "Forkhead box protein P1 expression in mucosa-associated lymphoid tissue lymphomas predicts poor prognosis and transformation to diffuse large B-cell lymphoma". J. Clin. Oncol. 24 (16): 2490–7. doi:10.1200/JCO.2006.05.6150. PMID 16636337. 
• Haralambieva E, Adam P, Ventura R, (2007). "Genetic rearrangement of FOXP1 is predominantly detected in a subset of diffuse large B-cell lymphomas with extranodal presentation". Leukemia 20 (7): 1300–3. doi:10.1038/sj.leu.2404244. PMID 16673020. 
• Hannenhalli S, Putt ME, Gilmore JM, (2006). "Transcriptional genomics associates FOX transcription factors with human heart failure". Circulation 114 (12): 1269–76. doi:10.1161/CIRCULATIONAHA.106.632430. PMID 16952980. 

External links

• MeSH FOXP1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.