KLF8

Kruppel-like factor 8
Identifiers
Symbols	KLF8; BKLF3; DKFZp686O08126; MGC138314; ZNF741
External IDs	OMIM: 300286 MGI: 2442430 HomoloGene: 68549 GeneCards: KLF8 Gene
Gene Ontology Molecular function • DNA binding • zinc ion binding • metal ion binding Cellular component • intracellular • nucleus Biological process • regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11279	245671
Ensembl	ENSG00000102349	ENSMUSG00000041649
UniProt	O95600	n/a
RefSeq (mRNA)	NM_001159296.1	NM_173780.4
RefSeq (protein)	NP_001152768.1	NP_776141.1
Location (UCSC)	Chr X: 56.26 – 56.31 Mb	Chr X: 149.67 – 149.83 Mb
PubMed search	[1]	[2]

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene.

Interactions

KLF8 has been shown to interact with CTBP2.

Further reading

• van Vliet J, Turner J, Crossley M (2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription.". Nucleic Acids Res. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=103308. 
• Lossi AM, Laugier-Anfossi F, Depetris D, et al. (2002). "Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation.". J. Med. Genet. 39 (2): 113–7. doi:10.1136/jmg.39.2.113. PMC 1735036. PMID 11836360. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1735036. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Turner J, Nicholas H, Bishop D, et al. (2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2.". J. Biol. Chem. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451. 
• Zhao J, Bian ZC, Yee K, et al. (2003). "Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression.". Mol. Cell 11 (6): 1503–15. doi:10.1016/S1097-2765(03)00179-5. PMID 12820964. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665286. 
• Zhang P, Basu P, Redmond LC, et al. (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.". Blood Cells Mol. Dis. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392. 
• Wang X, Zhao J (2007). "KLF8 transcription factor participates in oncogenic transformation.". Oncogene 26 (3): 456–61. doi:10.1038/sj.onc.1209796. PMID 16832343. 
• Hu JH, Navas P, Cao H, et al. (2007). "Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation.". J. Mol. Biol. 366 (4): 1064–73. doi:10.1016/j.jmb.2006.12.047. PMC 1907364. PMID 17224162. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1907364. 
• Wang X, Zheng M, Liu G, et al. (2007). "Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion.". Cancer Res. 67 (15): 7184–93. doi:10.1158/0008-5472.CAN-06-4729. PMID 17671186. 

External links

• MeSH KLF8 protein, human