ETS2

V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
PDB rendering based on 1k78.
Available structures PDB 1k78, 1k79, 1k7a, 2stt, 2stw
Identifiers
Symbols	ETS2;
External IDs	OMIM: 164740 MGI: 95456 HomoloGene: 3838 GeneCards: ETS2 Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding Cellular component • nucleus Biological process • skeletal system development • transcription, DNA-dependent • transcription, DNA-dependent • regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2114	23872
Ensembl	ENSG00000157557	ENSMUSG00000022895
UniProt	P15036	Q3UAL8
RefSeq (mRNA)	NM_005239.4	NM_011809.3
RefSeq (protein)	NP_005230.1	NP_035939.3
Location (UCSC)	Chr 21: 40.18 – 40.2 Mb	Chr 16: 95.92 – 95.94 Mb
PubMed search	[1]	[2]

Protein C-ets-2 is a protein that in humans is encoded by the ETS2 gene. The protein encoded by this gene belongs to the ETS family of transcription factors.

Interactions

ETS2 has been shown to interact with ZMYND11, ERG, Cyclin-dependent kinase 10 and C-jun. myb,

Further reading

• Boulukos KE, Pognonec P, Sariban E, et al. (1990). "Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators.". Genes Dev. 4 (3): 401–9. doi:10.1101/gad.4.3.401. PMID 2186967. 
• Watson DK, Mavrothalassitis GJ, Jorcyk CL, et al. (1991). "Molecular organization and differential polyadenylation sites of the human ETS2 gene.". Oncogene 5 (10): 1521–7. PMID 2250910. 
• Watson DK, McWilliams MJ, Lapis P, et al. (1988). "Mammalian ets-1 and ets-2 genes encode highly conserved proteins.". Proc. Natl. Acad. Sci. U.S.A. 85 (21): 7862–6. doi:10.1073/pnas.85.21.7862. PMC 282297. PMID 2847145. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=282297. 
• Watson DK, McWilliams-Smith MJ, Nunn MF, et al. (1985). "The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active.". Proc. Natl. Acad. Sci. U.S.A. 82 (21): 7294–8. doi:10.1073/pnas.82.21.7294. PMC 391330. PMID 2997781. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=391330. 
• Le Beau MM, Rowley JD, Sacchi N, et al. (1986). "Hu-ets-2 is translocated to chromosome 8 in the t(8;21) in acute myelogenous leukemia.". Cancer Genet. Cytogenet. 23 (3): 269–74. doi:10.1016/0165-4608(86)90189-5. PMID 3021321. 
• Fujiwara S, Fisher RJ, Seth A, et al. (1988). "Characterization and localization of the products of the human homologs of the v-ets oncogene.". Oncogene 2 (2): 99–103. PMID 3285299. 
• Sumarsono SH, Wilson TJ, Tymms MJ, et al. (1996). "Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice.". Nature 379 (6565): 534–7. doi:10.1038/379534a0. PMID 8596630. 
• Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (1997). "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner.". J. Biol. Chem. 272 (42): 26188–95. doi:10.1074/jbc.272.42.26188. PMID 9334186. 
• Blumenthal SG, Aichele G, Wirth T, et al. (1999). "Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1.". J. Biol. Chem. 274 (18): 12910–6. doi:10.1074/jbc.274.18.12910. PMID 10212281. 
• Jayaraman G, Srinivas R, Duggan C, et al. (1999). "p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter.". J. Biol. Chem. 274 (24): 17342–52. doi:10.1074/jbc.274.24.17342. PMID 10358095. 
• Kilpatrick LM, Kola I, Salamonsen LA (1999). "Transcription factors Ets1, Ets2, and Elf1 exhibit differential localization in human endometrium across the menstrual cycle and alternate isoforms in cultured endometrial cells.". Biol. Reprod. 61 (1): 120–6. doi:10.1095/biolreprod61.1.120. PMID 10377039. 
• Rameil P, Lécine P, Ghysdael J, et al. (2000). "IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells.". Oncogene 19 (17): 2086–97. doi:10.1038/sj.onc.1203542. PMID 10815800. 
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953. 
• Park US, Park SK, Lee YI, et al. (2000). "Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1-->S transition via a p53-independent pathway in human hepatoma cells.". Oncogene 19 (30): 3384–94. doi:10.1038/sj.onc.1203674. PMID 10918595. 
• Pastorcic M, Das HK (2001). "Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene.". J. Biol. Chem. 275 (45): 34938–45. doi:10.1074/jbc.M005411200. PMID 10942770. 
• Smith JL, Schaffner AE, Hofmeister JK, et al. (2000). "ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice.". Mol. Cell. Biol. 20 (21): 8026–34. doi:10.1128/MCB.20.21.8026-8034.2000. PMC 86413. PMID 11027273. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86413. 
• Mullick J, Anandatheerthavarada HK, Amuthan G, et al. (2001). "Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter.". J. Biol. Chem. 276 (21): 18007–17. doi:10.1074/jbc.M100671200. PMID 11279115. 
• Kasten M, Giordano A (2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity.". Oncogene 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931. 
• Ezashi T, Ghosh D, Roberts RM (2001). "Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4.". Mol. Cell. Biol. 21 (23): 7883–91. doi:10.1128/MCB.21.23.7883-7891.2001. PMC 99954. PMID 11689681. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99954. 
• Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=64988. 

External links

• Drosophila pointed - The Interactive Fly