bZIP domain

bZIP transcription factor
	CREB (top) is a transcription factor capable of binding DNA via the bZIP domain (bottom) and regulating gene expression.
Identifiers
Symbol	bZIP_1
Pfam	PF00170
InterPro	IPR011616
PROSITE	PDOC00036
SCOP	1ysa
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

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This article is about the protein domain. For the compression algorithm, see Bzip2.

The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required for the dimerization of two DNA binding regions. The DNA binding region comprises a number of basic aminoacids such as arginine and lysine. Proteins containing this domain are transcription factors.^[1]^[2]

[edit] bZIP transcription factors

bZIP transcription factors are found in all organisms. A recent evolutionary study revealed that 4 bZIP genes were encoded by the genome of the most recent common ancestor of all plants.^[3] Interactions between bZIP transcription factors play important role in cancer development^[4] in epithelial tissues, steroid hormone synthesis by cells of endocrine tissues,^[5] factors affecting reproductive functions,^[6] and several other phenomena that affect human health.

[edit] bZIP domain containing proteins

AP-1 fos/jun heterodimer that forms a transcription factor
Jun-B transcription factor
CREB cAMP response element transcription factor
OPAQUE2 (O2) transcription factor of the 22-kD zein gene that encodes a class of storage proteins in the endosperm of maize (Zea Mays) kernels

[edit] Human proteins containing this domain

ATF1; ATF2; ATF4; ATF5; ATF6; ATF7; BACH1; BACH2; BATF; BATF2; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREB5; CREBL1; CREM; E4BP4; FOSL1; FOSL2; JUN; JUNB; JUND; MAFA; MAFB; NFE2; NFE2L2; NFE2L3; SNFT; CREM

[edit] External links

[edit] References

^ Ellenberger T (1994). "Getting a grip in DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains.". Curr. Opin. Struct. Biol. 4 (1): 12–21. doi:10.1016/S0959-440X(94)90054-X.
^ Hurst HC (1995). "Transcription factors 1: bZIP proteins". Protein Profile 2 (2): 101–68. PMID 7780801.
^ Corrêa LGG, Riaño-Pachón DM, Schrago CG, dos Santos RV, Mueller-Roeber B, Vincentz M. (2008). Shiu, Shin-Han. ed. "The Role of bZIP Transcription Factors in Green Plant Evolution: Adaptive Features Emerging from Four Founder Genes". PLos ONE 3 (8): e2944. doi:10.1371/journal.pone.0002944. PMC 2492810. PMID 18698409. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2492810.
^ Vlahopoulos SA, Logotheti S, Mikas D, Giarika A, Gorgoulis V, Zoumpourlis V (April 2008). "The role of ATF-2 in oncogenesis". Bioessays 30 (4): 314–27. doi:10.1002/bies.20734. PMID 18348191.
^ Manna PR, Dyson MT, Eubank DW, Clark BJ, Lalli E, Sassone-Corsi P, Zeleznik AJ, Stocco DM (January 2002). "Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family". Mol. Endocrinol. 16 (1): 184–99. doi:10.1210/me.16.1.184. PMID 11773448.
^ Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS (May 1999). "Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun". Endocrinology 140 (5): 2268–79. doi:10.1210/en.140.5.2268. PMID 10218980.

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[Ellenberger_1994-0] Ellenberger T (1994). "Getting a grip in DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains.". Curr. Opin. Struct. Biol. 4 (1): 12–21. doi:10.1016/S0959-440X(94)90054-X.

[pmid7780801-1] Hurst HC (1995). "Transcription factors 1: bZIP proteins". Protein Profile 2 (2): 101–68. PMID 7780801.

[pmid18698409-2] Corrêa LGG, Riaño-Pachón DM, Schrago CG, dos Santos RV, Mueller-Roeber B, Vincentz M. (2008). Shiu, Shin-Han. ed. "The Role of bZIP Transcription Factors in Green Plant Evolution: Adaptive Features Emerging from Four Founder Genes". PLos ONE 3 (8): e2944. doi:10.1371/journal.pone.0002944. PMC 2492810. PMID 18698409. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2492810.

[pmid18348191-3] Vlahopoulos SA, Logotheti S, Mikas D, Giarika A, Gorgoulis V, Zoumpourlis V (April 2008). "The role of ATF-2 in oncogenesis". Bioessays 30 (4): 314–27. doi:10.1002/bies.20734. PMID 18348191.

[pmid11773448-4] Manna PR, Dyson MT, Eubank DW, Clark BJ, Lalli E, Sassone-Corsi P, Zeleznik AJ, Stocco DM (January 2002). "Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family". Mol. Endocrinol. 16 (1): 184–99. doi:10.1210/me.16.1.184. PMID 11773448.

[pmid10218980-5] Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS (May 1999). "Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun". Endocrinology 140 (5): 2268–79. doi:10.1210/en.140.5.2268. PMID 10218980.

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bZIP domain

Contents

[edit] bZIP transcription factors

[edit] bZIP domain containing proteins

[edit] Human proteins containing this domain

[edit] External links

[edit] References

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