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From Wikipedia, the free encyclopedia
| Kruppel-like factor 13 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||
| Symbols | KLF13; BTEB3; FKLF2; NSLP1; RFLAT-1; RFLAT1 | |||||||
| External IDs | OMIM: 605328 MGI: 1354948 HomoloGene: 32288 GeneCards: KLF13 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 51621 | 50794 | ||||||
| Ensembl | ENSG00000169926 | ENSMUSG00000052040 | ||||||
| UniProt | Q9Y2Y9 | Q3U2G6 | ||||||
| RefSeq (mRNA) | NM_015995 | NM_021366.3 | ||||||
| RefSeq (protein) | NP_057079 | NP_067341.2 | ||||||
| Location (UCSC) | Chr 15: 31.62 – 31.67 Mb |
Chr 7: 71.03 – 71.08 Mb |
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| PubMed search | [1] | [2] |
Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.[1][2][3]
Contents |
[edit] Function
KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.[4][1]
KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1.[3] It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.[3][5][6][7][8][9][10]
[edit] Interactions
KLF13 has been shown to interact with CREB-binding protein,[11] Heat shock protein 47[11] and PCAF.[11]
[edit] See also
[edit] References
- ^ a b "Entrez Gene: KLF13 Kruppel-like factor 13". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51621.
- ^ Cook T, Gebelein B, Urrutia R (June 1999). "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors". Ann. N. Y. Acad. Sci. 880 (1 CELL AND MOLE): 94–102. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854.
- ^ a b c Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (January 1999). "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity 10 (1): 93–103. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
- ^ Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C (November 2000). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID 11087666.
- ^ Song A, Nikolcheva T, Krensky AM (October 2000). "Transcriptional regulation of RANTES expression in T lymphocytes". Immunol. Rev. 177 (1): 236–45. doi:10.1034/j.1600-065X.2000.17610.x. PMID 11138780.
- ^ Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM (July 2002). "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes". J. Clin. Invest. 110 (1): 119–26. doi:10.1172/JCI15336. PMC 151028. PMID 12093895. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=151028.
- ^ Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM (August 2002). "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes". J. Biol. Chem. 277 (33): 30055–65. doi:10.1074/jbc.M204278200. PMID 12050170.
- ^ Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C, Krensky AM (May 2007). "Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo". J. Immunol. 178 (9): 5496–504. PMC 2664650. PMID 17442931. http://www.jimmunol.org/cgi/content/abstract/178/9/5496.
- ^ Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM (June 2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". J. Immunol. 178 (11): 7081–7. PMC 2674583. PMID 17513757. http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=17513757.
- ^ Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM (January 2007). "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes". Mol. Cell. Biol. 27 (1): 253–66. doi:10.1128/MCB.01071-06. PMC 1800668. PMID 17074812. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1800668.
- ^ a b c Song, Chao-Zhong; Keller Kimberly, Murata Ken, Asano Haruhiko, Stamatoyannopoulos George (Mar. 2002). "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". J. Biol. Chem. (United States) 277 (9): 7029–36. doi:10.1074/jbc.M108826200. ISSN 0021-9258. PMC 2808425. PMID 11748222. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2808425.
[edit] Further reading
- Cook T, Gebelein B, Urrutia R (1999). "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors.". Ann. N. Y. Acad. Sci. 880 (1 CELL AND MOLE): 94–102. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854.
- Song A, Chen YF, Thamatrakoln K, et al. (1999). "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.". Immunity 10 (1): 93–103. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
- Asano H, Li XS, Stamatoyannopoulos G (2000). "FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes.". Blood 95 (11): 3578–84. PMID 10828046.
- Scohy S, Gabant P, Van Reeth T, et al. (2001). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family.". Genomics 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID 11087666.
- Kaczynski J, Zhang JS, Ellenrieder V, et al. (2001). "The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1.". J. Biol. Chem. 276 (39): 36749–56. doi:10.1074/jbc.M105831200. PMID 11477107.
- Song CZ, Keller K, Murata K, et al. (2002). "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2.". J. Biol. Chem. 277 (9): 7029–36. doi:10.1074/jbc.M108826200. PMC 2808425. PMID 11748222. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2808425.
- Kaczynski JA, Conley AA, Fernandez Zapico M, et al. (2002). "Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter.". Biochem. J. 366 (Pt 3): 873–82. doi:10.1042/BJ20020388. PMC 1222816. PMID 12036432. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222816.
- Song A, Patel A, Thamatrakoln K, et al. (2002). "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes.". J. Biol. Chem. 277 (33): 30055–65. doi:10.1074/jbc.M204278200. PMID 12050170.
- Nikolcheva T, Pyronnet S, Chou SY, et al. (2002). "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes.". J. Clin. Invest. 110 (1): 119–26. doi:10.1172/JCI15336. PMC 151028. PMID 12093895. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=151028.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Mitsuma A, Asano H, Kinoshita T, et al. (2005). "Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells.". Biochim. Biophys. Acta 1727 (2): 125–33. doi:10.1016/j.bbaexp.2004.12.007. PMC 2808416. PMID 15716005. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2808416.
- Zhang P, Basu P, Redmond LC, et al. (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.". Blood Cells Mol. Dis. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.
- Ahn YT, Huang B, McPherson L, et al. (2007). "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes.". Mol. Cell. Biol. 27 (1): 253–66. doi:10.1128/MCB.01071-06. PMC 1800668. PMID 17074812. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1800668.
- Huang B, Ahn YT, McPherson L, et al. (2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.". J. Immunol. 178 (11): 7081–7. PMC 2674583. PMID 17513757. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2674583.
[edit] External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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