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P09023 (HXB6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 31, 2012. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B6
Alternative name(s):
Homeobox protein Hox-2.2
Homeobox protein MH-22A
Gene names
Name:Hoxb6
Synonyms:Hox-2.2, Hoxb-6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 224224Homeobox protein Hox-B6
PRO_0000200136

Regions

DNA binding146 – 20560Homeobox
Motif127 – 1326Antp-type hexapeptide
Compositional bias216 – 2205Poly-Glu

Amino acid modifications

Modified residue2111Phosphoserine By similarity
Modified residue2141Phosphoserine By similarity

Experimental info

Sequence conflict1861T → P in AAA37844. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P09023 [UniParc].

Last modified July 1, 1989. Version 2.
Checksum: E8FC0BDEB57F5C3D

FASTA22425,310
        10         20         30         40         50         60 
MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD KGFAASSYYP 

        70         80         90        100        110        120 
PAGGGYGRAA PCDYGPAPAF YREKDAACAL SGADEPPPFH PEPRKSDCAQ DKSVFGETEE 

       130        140        150        160        170        180 
QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA 

       190        200        210        220 
HALCLTERQI KIWFQNRRMK WKKESKLLSA SQLSAEEEEE KPAE

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of Hox-2.2, a murine homeobox-containing gene."
Schughart K., Utset M.F., Awgulewitsch A., Ruddle F.H.
Proc. Natl. Acad. Sci. U.S.A. 85:5582-5586(1988) [PubMed: 2899893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues."
Shen W.-F., Detmer K., Simonitch-Eason T.A., Lawrence H.J., Largman C.
Nucleic Acids Res. 19:539-545(1991) [PubMed: 1672751] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
[4]"New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis."
Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.
DNA 6:409-418(1987) [PubMed: 2890503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-224.
[5]"Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons."
Hart C.P., Fainsod A., Ruddle F.H.
Genomics 1:182-195(1987) [PubMed: 2891608] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 140-224.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M18166 Genomic DNA. Translation: AAA37844.1.
X56459 mRNA. Translation: CAA39834.1.
BC016893 mRNA. Translation: AAH16893.1.
M18401 Genomic DNA. Translation: AAC27130.1. Sequence problems.
J03782 Genomic DNA. Translation: AAA37843.1.
IPIIPI00132375.
PIRA31324.
B29585.
C27176.
RefSeqNP_032295.1. NM_008269.1.
UniGeneMm.215.

3D structure databases

ProteinModelPortalP09023.
SMRP09023. Positions 150-205.
ModBaseSearch...

Protein-protein interaction databases

STRINGP09023.

PTM databases

PhosphoSiteP09023.

Proteomic databases

PRIDEP09023.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000704; ENSMUSP00000000704; ENSMUSG00000000690.
ENSMUST00000173432; ENSMUSP00000133281; ENSMUSG00000000690.
GeneID15414.
KEGGmmu:15414.

Organism-specific databases

CTD3216.
MGIMGI:96187. Hoxb6.

Phylogenomic databases

eggNOGNOG305812.
GeneTreeENSGT00680000099610.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidP09023.
KOK09306.
OMAAFHPEPR.
OrthoDBEOG4G7C0G.

Gene expression databases

ArrayExpressP09023.
BgeeP09023.
CleanExMM_HOXB6.
GenevestigatorP09023.
GermOnlineENSMUSG00000000690. Mus musculus.

Family and domain databases

Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_metazoa.
IPR001356. Homeodomain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. Homeodomain_like. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288142.
SOURCESearch...

Entry information

Entry nameHXB6_MOUSE
AccessionPrimary (citable) accession number: P09023
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: October 31, 2012
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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