JARID1B

Lysine (K)-specific demethylase 5B
Identifiers
Symbols	KDM5B; CT31; FLJ10538; FLJ12459; FLJ12491; FLJ16281; FLJ23670; JARID1B; PLU-1; PLU1; PUT1; RBBP2H1A
External IDs	OMIM: 605393 MGI: 1922855 HomoloGene: 48448 GeneCards: KDM5B Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • transcription corepressor activity • protein binding • zinc ion binding • oxidoreductase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • histone demethylase activity (H3-trimethyl-K4 specific) • histone demethylase activity (H3-dimethyl-K4 specific) • metal ion binding Cellular component • intracellular • nucleus • nucleolus • intracellular membrane-bounded organelle Biological process • transcription, DNA-dependent • regulation of transcription, DNA-dependent • chromatin modification • histone H3-K4 demethylation • histone H3-K4 demethylation, trimethyl-H3-K4-specific • negative regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10765	75605
Ensembl	ENSG00000117139	ENSMUSG00000042207
UniProt	Q9UGL1	Q80Y84
RefSeq (mRNA)	NM_006618	NM_152895.2
RefSeq (protein)	NP_006609	NP_690855.2
Location (UCSC)	Chr 1: 200.96 – 201.05 Mb	Chr 1: 136.46 – 136.53 Mb
PubMed search	[1]	[2]

Lysine-specific demethylase 5B also known as histone demethylase JARID1B is a demethylase enzyme that in humans is encoded by the KDM5B gene.

Interactions

JARID1B has been shown to interact with FOXG1 and PAX9.

Further reading

• Lu PJ, Sundquist K, Baeckstrom D, et al. (1999). "A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer.". J. Biol. Chem. 274 (22): 15633–45. doi:10.1074/jbc.274.22.15633. PMID 10336460. 
• Kashuba V, Protopopov A, Podowski R, et al. (2000). "Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A).". Eur. J. Hum. Genet. 8 (6): 407–13. doi:10.1038/sj.ejhg.5200474. PMID 10878660. 
• Barrett A, Madsen B, Copier J, et al. (2002). "PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?". Int. J. Cancer 101 (6): 581–8. doi:10.1002/ijc.10644. PMID 12237901. 
• Tan K, Shaw AL, Madsen B, et al. (2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9.". J. Biol. Chem. 278 (23): 20507–13. doi:10.1074/jbc.M301994200. PMID 12657635. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins". Nucleic Acids Res. 33 (1): 66–80. doi:10.1093/nar/gki145. PMC 546134. PMID 15640446. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=546134. 
• Tzschach A, Lenzner S, Moser B, et al. (2006). "Novel JARID1C/SMCX mutations in patients with X-linked mental retardation". Hum. Mutat. 27 (4): 389. doi:10.1002/humu.9420. PMID 16541399. 
• Yamane K, Tateishi K, Klose RJ, et al. (2007). "PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation". Mol. Cell 25 (6): 801–12. doi:10.1016/j.molcel.2007.03.001. PMID 17363312. 
• Barrett A, Santangelo S, Tan K, et al. (2007). "Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases". Int. J. Cancer 121 (2): 265–75. doi:10.1002/ijc.22673. PMID 17373667. 

External links

• MeSH JARID1B+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.