SOX5

SRY (sex determining region Y)-box 5
PDB rendering based on 1i11.
Available structures PDB 1i11
Identifiers
Symbols	SOX5; L-SOX5; MGC35153
External IDs	OMIM: 604975 MGI: 98367 HomoloGene: 21378 GeneCards: SOX5 Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • protein binding Cellular component • nucleus Biological process • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6660	20678
Ensembl	ENSG00000134532	ENSMUSG00000041540
UniProt	P35711	Q3TVF9
RefSeq (mRNA)	NM_006940.4	NM_011444
RefSeq (protein)	NP_008871.3	NP_035574
Location (UCSC)	Chr 12: 23.68 – 24.1 Mb	Chr 6: 143.78 – 144.73 Mb
PubMed search	[1]	[2]

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

See also

• SOX genes

Further reading

• Kamachi Y, Uchikawa M, Kondoh H (2000). "Pairing SOX off: with partners in the regulation of embryonic development.". Trends Genet. 16 (4): 182–7. doi:10.1016/S0168-9525(99)01955-1. PMID 10729834. 
• Bowles J, Schepers G, Koopman P (2001). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.". Dev. Biol. 227 (2): 239–55. doi:10.1006/dbio.2000.9883. PMID 11071752. 
• Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890. 
• Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.". Dev. Cell 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848. 
• Denny P, Swift S, Brand N et al. (1992). "A conserved family of genes related to the testis determining gene, SRY". Nucleic Acids Res. 20 (11): 2887–2887. doi:10.1093/nar/20.11.2887. PMC 336939. PMID 1614875. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=336939. 
• Connor F, Cary PD, Read CM et al. (1994). "DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5". Nucleic Acids Res. 22 (16): 3339–46. doi:10.1093/nar/22.16.3339. PMC 523727. PMID 8078769. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=523727. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Lefebvre V, Li P, de Crombrugghe B (1998). "A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene". EMBO J. 17 (19): 5718–33. doi:10.1093/emboj/17.19.5718. PMC 1170900. PMID 9755172. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170900. 
• Uusitalo H, Hiltunen A, Ahonen M et al. (2002). "Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing". J. Bone Miner. Res. 16 (10): 1837–45. doi:10.1359/jbmr.2001.16.10.1837. PMID 11585348. 
• Zafarana G, Gillis AJ, van Gurp RJ et al. (2002). "Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation". Cancer Res. 62 (6): 1822–31. PMID 11912161. 
• Ikeda T, Zhang J, Chano T et al. (2003). "Identification and characterization of the human long form of Sox5 (L-SOX5) gene". Gene 298 (1): 59–68. doi:10.1016/S0378-1119(02)00927-7. PMID 12406576. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.