IRF4

Interferon regulatory factor 4
	; PDB rendering based on 2dll.
Available structures
PDB	2dll
Identifiers
Symbols	IRF4; LSIRF; MUM1
External IDs	OMIM: 601900 MGI: 1096873 HomoloGene: 1842 GeneCards: IRF4 Gene
Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity; • transcription factor binding;
Cellular component	• nuclear nucleosome; • nucleus; • nucleus; • nucleolus; • cytoplasm;
Biological process	• transcription, DNA-dependent; • regulation of transcription, DNA-dependent; • cytokine-mediated signaling pathway; • T cell activation; • myeloid dendritic cell differentiation; • positive regulation of DNA binding; • histone H3 acetylation; • histone H4 acetylation; • positive regulation of interleukin-10 biosynthetic process; • positive regulation of interleukin-2 biosynthetic process; • positive regulation of interleukin-13 biosynthetic process; • positive regulation of interleukin-4 biosynthetic process; • regulation of T-helper cell differentiation; • positive regulation of transcription, DNA-dependent; • interferon-gamma-mediated signaling pathway; • type I interferon-mediated signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Interferon regulatory factor 4 is a protein that in humans is encoded by the IRF4 gene,^[1]^[2]^[3] also known as MUM1. In melanocytic cells the IRF4 gene may be regulated by MITF.^[4]

[edit] Interactions

IRF4 has been shown to interact with STAT6,^[5] NFATC2,^[6] BCL6^[5] and SPI1.^[7]^[8]

[edit] See also

Interferon regulatory factors

[edit] References

^ Grossman A, Mittrucker HW, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland GR, Siderovski DP, Mak TW (Feb 1997). "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25". Genomics 37 (2): 229–33. doi:10.1006/geno.1996.0547. PMID 8921401.
^ Xu D, Zhao L, Del Valle L, Miklossy J, Zhang L (Jun 2008). "Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes". J Virol 82 (13): 6251–8. doi:10.1128/JVI.00163-08. PMC 2447047. PMID 18417578. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2447047.
^ "Entrez Gene: IRF4 interferon regulatory factor 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3662.
^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
^ ^a ^b Gupta, S; Jiang M, Anthony A, Pernis A B (Dec. 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. (UNITED STATES) 190 (12): 1837–48. doi:10.1084/jem.190.12.1837. ISSN 0022-1007. PMC 2195723. PMID 10601358. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2195723.
^ Rengarajan, Jyothi; Mowen Kerri A, McBride Kathryn D, Smith Erica D, Singh Harinder, Glimcher Laurie H (Apr. 2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression". J. Exp. Med. (United States) 195 (8): 1003–12. doi:10.1084/jem.20011128. ISSN 0022-1007. PMC 2193700. PMID 11956291. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193700.
^ Brass, A L; Zhu A Q, Singh H (Feb. 1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers". EMBO J. (ENGLAND) 18 (4): 977–91. doi:10.1093/emboj/18.4.977. ISSN 0261-4189. PMC 1171190. PMID 10022840. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171190.
^ Escalante, Carlos R; Shen Leyi, Escalante Mary C, Brass Abraham L, Edwards Thomas A, Singh Harinder, Aggarwal Aneel K (Jul. 2002). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex". J. Struct. Biol. (United States) 139 (1): 55–9. doi:10.1016/S1047-8477(02)00514-2. ISSN 1047-8477. PMID 12372320.

[edit] Further reading

Mamane Y, Sharma S, Grandvaux N, et al. (2002). "IRF-4 activities in HTLV-I-induced T cell leukemogenesis.". J. Interferon Cytokine Res. 22 (1): 135–43. doi:10.1089/107999002753452746. PMID 11846984.
Yamagata T, Nishida J, Tanaka S, et al. (1996). "A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes.". Mol. Cell. Biol. 16 (4): 1283–94. PMC 231112. PMID 8657101. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231112.
Iida S, Rao PH, Butler M, et al. (1997). "Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma.". Nat. Genet. 17 (2): 226–30. doi:10.1038/ng1097-226. PMID 9326949.
Brass AL, Zhu AQ, Singh H (1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers.". EMBO J. 18 (4): 977–91. doi:10.1093/emboj/18.4.977. PMC 1171190. PMID 10022840. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171190.
Rao S, Matsumura A, Yoon J, Simon MC (1999). "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.". J. Biol. Chem. 274 (16): 11115–24. doi:10.1074/jbc.274.16.11115. PMID 10196196.
Marecki S, Atchison ML, Fenton MJ (1999). "Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophages.". J. Immunol. 163 (5): 2713–22. PMID 10453013.
Gupta S, Jiang M, Anthony A, Pernis AB (2000). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4.". J. Exp. Med. 190 (12): 1837–48. doi:10.1084/jem.190.12.1837. PMC 2195723. PMID 10601358. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2195723.
Mamane Y, Sharma S, Petropoulos L, et al. (2000). "Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52.". Immunity 12 (2): 129–40. doi:10.1016/S1074-7613(00)80166-1. PMID 10714679.
Gupta S, Anthony A, Pernis AB (2001). "Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins.". J. Immunol. 166 (10): 6104–11. PMID 11342629.
Imaizumi Y, Kohno T, Yamada Y, et al. (2002). "Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia.". Jpn. J. Cancer Res. 92 (12): 1284–92. PMID 11749693.
Rengarajan J, Mowen KA, McBride KD, et al. (2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression.". J. Exp. Med. 195 (8): 1003–12. doi:10.1084/jem.20011128. PMC 2193700. PMID 11956291. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193700.
Sharma S, Grandvaux N, Mamane Y, et al. (2002). "Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells.". J. Immunol. 169 (6): 3120–30. PMID 12218129.
Escalante CR, Shen L, Escalante MC, et al. (2003). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex.". J. Struct. Biol. 139 (1): 55–9. doi:10.1016/S1047-8477(02)00514-2. PMID 12372320.
Hu CM, Jang SY, Fanzo JC, Pernis AB (2003). "Modulation of T cell cytokine production by interferon regulatory factor-4.". J. Biol. Chem. 277 (51): 49238–46. doi:10.1074/jbc.M205895200. PMID 12374808.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Fanzo JC, Hu CM, Jang SY, Pernis AB (2003). "Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4).". J. Exp. Med. 197 (3): 303–14. doi:10.1084/jem.20020717. PMC 2193834. PMID 12566414. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193834.
O'Reilly D, Quinn CM, El-Shanawany T, et al. (2003). "Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner.". J. Biol. Chem. 278 (24): 21909–19. doi:10.1074/jbc.M212150200. PMID 12676954.
Sundram U, Harvell JD, Rouse RV, Natkunam Y (2004). "Expression of the B-cell proliferation marker MUM1 by melanocytic lesions and comparison with S100, gp100 (HMB45), and MelanA.". Mod. Pathol. 16 (8): 802–10. doi:10.1097/01.MP.0000081726.49886.CF. PMID 12920225.

[edit] External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it.

[pmid8921401-0] Grossman A, Mittrucker HW, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland GR, Siderovski DP, Mak TW (Feb 1997). "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25". Genomics 37 (2): 229–33. doi:10.1006/geno.1996.0547. PMID 8921401.

[pmid18417578-1] Xu D, Zhao L, Del Valle L, Miklossy J, Zhang L (Jun 2008). "Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes". J Virol 82 (13): 6251–8. doi:10.1128/JVI.00163-08. PMC 2447047. PMID 18417578. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2447047.

[entrez-2] "Entrez Gene: IRF4 interferon regulatory factor 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3662.

[pmid19067971-3] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

[pmid10601358-4] Gupta, S; Jiang M, Anthony A, Pernis A B (Dec. 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. (UNITED STATES) 190 (12): 1837–48. doi:10.1084/jem.190.12.1837. ISSN 0022-1007. PMC 2195723. PMID 10601358. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2195723.

[pmid11956291-5] Rengarajan, Jyothi; Mowen Kerri A, McBride Kathryn D, Smith Erica D, Singh Harinder, Glimcher Laurie H (Apr. 2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression". J. Exp. Med. (United States) 195 (8): 1003–12. doi:10.1084/jem.20011128. ISSN 0022-1007. PMC 2193700. PMID 11956291. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193700.

[pmid10022840-6] Brass, A L; Zhu A Q, Singh H (Feb. 1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers". EMBO J. (ENGLAND) 18 (4): 977–91. doi:10.1093/emboj/18.4.977. ISSN 0261-4189. PMC 1171190. PMID 10022840. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171190.

[pmid12372320-7] Escalante, Carlos R; Shen Leyi, Escalante Mary C, Brass Abraham L, Edwards Thomas A, Singh Harinder, Aggarwal Aneel K (Jul. 2002). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex". J. Struct. Biol. (United States) 139 (1): 55–9. doi:10.1016/S1047-8477(02)00514-2. ISSN 1047-8477. PMID 12372320.

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Nov	DEC	Jan
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2010	2011	2012

IRF4

[edit] Interactions

[edit] See also

[edit] References

[edit] Further reading

[edit] External links

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