FOXJ1

Forkhead box protein J1 is a protein that in humans is encoded by the FOXJ1 gene. It has been shown that this gene is a transcription factor involved in ciliogenesis.

forkhead box J1
Identifiers
Symbols	FOXJ1; MGC35202; FKHL13; HFH4
External IDs	OMIM: 602291 MGI: 1347474 HomoloGene: 1117 GeneCards: FOXJ1 Gene
Gene Ontology Molecular function • protein binding • sequence-specific DNA binding • transcription factor activity Cellular component • nucleus Biological process • regulation of transcription, DNA-dependent • spermatogenesis • pattern specification process • activation of Rho GTPase activity • negative regulation of B cell activation • negative regulation of T cell proliferation • humoral immune response • negative regulation of interleukin-6 biosynthetic process • negative regulation of NF-kappaB transcription factor activity • central tolerance induction • positive regulation of central B cell tolerance induction • actin cytoskeleton organization • leukocyte migration • negative regulation of humoral immune response mediated by circulating immunoglobulin • negative regulation of gene-specific transcription from RNA polymerase II promoter • cilium assembly • transcription • negative regulation of germinal center formation • establishment of apical/basal cell polarity • negative regulation of T cell differentiation in the thymus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2302	15223
Ensembl	ENSG00000129654	ENSMUSG00000034227
UniProt	Q92949	Q61660
RefSeq (mRNA)	NM_001454	NM_008240
RefSeq (protein)	NP_001445	NP_032266
Location (UCSC)	Chr 17: 71.64 – 71.65 Mb	Chr 11: 116.19 – 116.2 Mb
PubMed search	[1]	[2]

Function

This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry.

Clinical significance

Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.

Further reading

• Li CS, Zhang Q, Lim MK, et al. (2007). "Association of FOXJ1 polymorphisms with systemic lupus erythematosus and rheumatoid arthritis in Korean population.". Exp. Mol. Med. 39 (6): 805–11. PMID 18160851. 
• Li CS, Chae SC, Lee JH, et al. (2006). "Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis.". J. Hum. Genet. 51 (4): 292–7. doi:10.1007/s10038-006-0359-8. PMID 16518568. 
• Turner J, Roger J, Fitau J, et al. (2011). "Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium.". Am. J. Respir. Cell Mol. Biol. 44 (3): 276–84. doi:10.1165/rcmb.2009-0304OC. PMID 20539013. 
• Murphy DB, Seemann S, Wiese S, et al. (1997). "The human hepatocyte nuclear factor 3/fork head gene FKHL13: genomic structure and pattern of expression.". Genomics 40 (3): 462–9. doi:10.1006/geno.1996.4587. PMID 9073514. 
• Maiti AK, Bartoloni L, Mitchison HM, et al. (2000). "No deleterious mutations in the FOXJ1 (alias HFH-4) gene in patients with primary ciliary dyskinesia (PCD).". Cytogenet. Cell Genet. 90 (1-2): 119–22. PMID 11060460. 
• LeSimple P, van Seuningen I, Buisine MP, et al. (2007). "Trefoil factor family 3 peptide promotes human airway epithelial ciliated cell differentiation.". Am. J. Respir. Cell Mol. Biol. 36 (3): 296–303. doi:10.1165/rcmb.2006-0270OC. PMID 17008636. 
• Lim L, Zhou H, Costa RH (1997). "The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3094–9. PMID 9096351. 
• Pelletier GJ, Brody SL, Liapis H, et al. (1998). "A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium.". Am. J. Physiol. 274 (3 Pt 1): L351-9. PMID 9530170. 
• Wu C, Ma MH, Brown KR, et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.". Proteomics 7 (11): 1775–85. doi:10.1002/pmic.200601006. PMID 17474147. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.