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From Wikipedia, the free encyclopedia
Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.[1][2][3]
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.[3]
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[edit] See also
[edit] References
- ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ^ a b "Entrez Gene: HOXB2 homeobox B2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3212.
[edit] Further reading
- Lavelle D, Ducksworth J, Eves E, et al. (1991). "A homeodomain protein binds to gamma-globin gene regulatory sequences.". Proc. Natl. Acad. Sci. U.S.A. 88 (16): 7318–22. doi:10.1073/pnas.88.16.7318. PMC 52286. PMID 1871139. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52286.
- Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
- Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=335308.
- Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652.
- Kongsuwan K, Webb E, Housiaux P, Adams JM (1988). "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages.". EMBO J. 7 (7): 2131–8. PMC 454515. PMID 2901346. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=454515.
- Vieille-Grosjean I, Huber P (1995). "Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells.". J. Biol. Chem. 270 (9): 4544–50. doi:10.1074/jbc.270.9.4544. PMID 7876223.
- Guazzi S, Lonigro R, Pintonello L, et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.". EMBO J. 13 (14): 3339–47. PMC 395231. PMID 7913891. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395231.
- Guazzi S, Pintonello ML, Viganò A, Boncinelli E (1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells.". J. Biol. Chem. 273 (18): 11092–9. doi:10.1074/jbc.273.18.11092. PMID 9556594.
- Davenne M, Maconochie MK, Neun R, et al. (1999). "Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain.". Neuron 22 (4): 677–91. doi:10.1016/S0896-6273(00)80728-X. PMID 10230789.
- Case SS, Huber P, Lloyd JA (2000). "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation.". DNA Cell Biol. 18 (11): 805–17. doi:10.1089/104454999314809. PMID 10595394.
- Golpon HA, Geraci MW, Moore MD, et al. (2001). "HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema.". Am. J. Pathol. 158 (3): 955–66. doi:10.1016/S0002-9440(10)64042-4. PMC 1850338. PMID 11238043. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850338.
- Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity.". Mol. Cell. Biol. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99922.
- Liu X, Zhang X (2002). "Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells.". Chin. J. Traumatol. 5 (1): 12–5. PMID 11835749.
- Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ivins S, Pemberton K, Guidez F, et al. (2003). "Regulation of Hoxb2 by APL-associated PLZF protein.". Oncogene 22 (24): 3685–97. doi:10.1038/sj.onc.1206328. PMID 12802276.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Segara D, Biankin AV, Kench JG, et al. (2005). "Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia.". Clin. Cancer Res. 11 (9): 3587–96. doi:10.1158/1078-0432.CCR-04-1813. PMID 15867264.
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