GFI1

Growth factor independent 1 transcription repressor
Identifiers
Symbols	GFI1; FLJ94509; GFI-1; SCN2; ZNF163
External IDs	OMIM: 600871 MGI: 103170 HomoloGene: 3854 GeneCards: GFI1 Gene
Gene Ontology Molecular function • DNA binding • protein binding • zinc ion binding • transcription regulatory region DNA binding • metal ion binding Cellular component • intracellular • nucleus Biological process • regulation of transcription involved in G1/S phase of mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-dependent • negative regulation of calcidiol 1-monooxygenase activity • negative regulation of vitamin D biosynthetic process • viral reproduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2672	14581
Ensembl	ENSG00000162676	ENSMUSG00000029275
UniProt	Q99684	P70338
RefSeq (mRNA)	NM_001127215.1	NM_010278.2
RefSeq (protein)	NP_001120687.1	NP_034408.1
Location (UCSC)	Chr 1: 92.94 – 92.95 Mb	Chr 5: 107.96 – 107.97 Mb
PubMed search	[1]	[2]

Zinc finger protein Gfi-1 is a protein that in humans is encoded by the GFI1 gene.

Interactions

GFI1 has been shown to interact with PIAS3 and RUNX1T1.

Further reading

• Gilks CB, Bear SE, Grimes HL, Tsichlis PN (1993). "Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein". Mol. Cell. Biol. 13 (3): 1759–68. PMC 359488. PMID 8441411. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=359488. 
• Zweidler-Mckay PA, Grimes HL, Flubacher MM, Tsichlis PN (1996). "Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor". Mol. Cell. Biol. 16 (8): 4024–34. PMC 231398. PMID 8754800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231398. 
• Roberts T, Cowell JK (1997). "Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22". Oncogene 14 (8): 1003–5. doi:10.1038/sj.onc.1200910. PMID 9051000. 
• Rödel B, Tavassoli K, Karsunky H, et al. (2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3". EMBO J. 19 (21): 5845–55. doi:10.1093/emboj/19.21.5845. PMC 305799. PMID 11060035. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305799. 
• Osawa M, Yamaguchi T, Nakamura Y, et al. (2002). "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis". Blood 100 (8): 2769–77. doi:10.1182/blood-2002-01-0182. PMID 12351384. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Person RE, Li FQ, Duan Z, et al. (2003). "Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2". Nat. Genet. 34 (3): 308–12. doi:10.1038/ng1170. PMC 2832179. PMID 12778173. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2832179. 
• McGhee L, Bryan J, Elliott L, et al. (2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism". J. Cell. Biochem. 89 (5): 1005–18. doi:10.1002/jcb.10548. PMID 12874834. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Doan LL, Porter SD, Duan Z, et al. (2004). "Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells". Nucleic Acids Res. 32 (8): 2508–19. doi:10.1093/nar/gkh570. PMC 419458. PMID 15131254. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=419458. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Dwivedi PP, Anderson PH, Omdahl JL, et al. (2005). "Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells". Endocr. Relat. Cancer 12 (2): 351–65. doi:10.1677/erc.1.00920. PMID 15947108. 
• Duan Z, Zarebski A, Montoya-Durango D, et al. (2005). "Gfi1 Coordinates Epigenetic Repression of p21Cip/WAF1 by Recruitment of Histone Lysine Methyltransferase G9a and Histone Deacetylase 1". Mol. Cell. Biol. 25 (23): 10338–51. doi:10.1128/MCB.25.23.10338-10351.2005. PMC 1291230. PMID 16287849. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1291230. 
• Marteijn JA, van der Meer LT, Van Emst L, et al. (2007). "Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes". Blood 109 (1): 100–8. doi:10.1182/blood-2006-02-003590. PMID 16888099. 
• Dwivedi PP, Anderson PH, Tilley WD, et al. (2007). "Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells". J. Steroid Biochem. Mol. Biol. 103 (3–5): 742–6. doi:10.1016/j.jsbmb.2006.12.014. PMID 17207994. 
• Nakazawa Y, Suzuki M, Manabe N, et al. (2007). "Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression". Oncogene 26 (24): 3541–50. doi:10.1038/sj.onc.1210140. PMID 17213822. 
• Khanna-Gupta A, Sun H, Zibello T, et al. (2007). "Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPϵ gene". Blood 109 (10): 4181–90. doi:10.1182/blood-2005-05-022004. PMC 1885490. PMID 17244686. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1885490. 
• Marteijn JA, van der Meer LT, van Emst L, et al. (2007). "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1". Blood 110 (9): 3128–35. doi:10.1182/blood-2006-11-058602. PMID 17646546. 

External links

• MeSH GFI1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.