BACH2

BTB and CNC homology 1, basic leucine zipper transcription factor 2
Identifiers
Symbols	BACH2;
External IDs	OMIM: 605394 HomoloGene: 7240 GeneCards: BACH2 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding • protein dimerization activity Cellular component • nucleus Biological process • transcription • regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	60468	n/a
Ensembl	ENSG00000112182	n/a
UniProt	Q9BYV9	n/a
RefSeq (mRNA)	NM_001170794.1	n/a
RefSeq (protein)	NP_001164265.1	n/a
Location (UCSC)	Chr 6: 90.64 – 91.01 Mb	n/a
PubMed search	[1]	n/a

Transcription regulator protein BACH2 is a protein that in humans is encoded by the BACH2 gene.

Further reading

• Oyake T, Itoh K, Motohashi H, et al. (1996). "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.". Mol. Cell. Biol. 16 (11): 6083–95. PMC 231611. PMID 8887638. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231611. 
• Kobayashi A, Yamagiwa H, Hoshino H, et al. (2000). "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain.". Mol. Cell. Biol. 20 (5): 1733–46. doi:10.1128/MCB.20.5.1733-1746.2000. PMC 85356. PMID 10669750. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85356. 
• Hoshino H, Kobayashi A, Yoshida M, et al. (2000). "Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element.". J. Biol. Chem. 275 (20): 15370–6. doi:10.1074/jbc.275.20.15370. PMID 10809773. 
• Vieira SA, Deininger MW, Sorour A, et al. (2002). "Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene.". Genes Chromosomes Cancer 32 (4): 353–63. doi:10.1002/gcc.1200. PMID 11746976. 
• Muto A, Tashiro S, Tsuchiya H, et al. (2002). "Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies.". J. Biol. Chem. 277 (23): 20724–33. doi:10.1074/jbc.M112003200. PMID 11923289. 
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
• Takakuwa T, Luo WJ, Ham MF, et al. (2004). "Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression.". Am. J. Pathol. 164 (3): 967–74. doi:10.1016/S0002-9440(10)63184-7. PMC 1614712. PMID 14982850. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1614712. 
• Tashiro S, Muto A, Tanimoto K, et al. (2004). "Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2.". Mol. Cell. Biol. 24 (8): 3473–84. doi:10.1128/MCB.24.8.3473-3484.2004. PMC 381671. PMID 15060166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=381671. 
• Motamed-Khorasani A, Jurisica I, Letarte M, et al. (2007). "Differentially androgen-modulated genes in ovarian epithelial cells from BRCA mutation carriers and control patients predict ovarian cancer survival and disease progression.". Oncogene 26 (2): 198–214. doi:10.1038/sj.onc.1209773. PMID 16832351. 
• Yoshida C, Yoshida F, Sears DE, et al. (2007). "Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1.". Blood 109 (3): 1211–9. doi:10.1182/blood-2005-12-040972. PMID 17018862. 
• Ono A, Kono K, Ikebe D, et al. (2007). "Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells.". Genes Chromosomes Cancer 46 (1): 67–74. doi:10.1002/gcc.20390. PMID 17044046. 
• Ikeda T, Shibata J, Yoshimura K, et al. (2007). "Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy.". J. Infect. Dis. 195 (5): 716–25. doi:10.1086/510915. PMID 17262715. 
• Hoshino H, Nishino TG, Tashiro S, et al. (2007). "Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression.". J. Biochem. 141 (5): 719–27. doi:10.1093/jb/mvm073. PMID 17383980. 

External links

• MeSH BACH2+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.