CEBPE

CCAAT/enhancer binding protein (C/EBP), epsilon
Identifiers
Symbols	CEBPE; C/EBP-epsilon; CRP1
External IDs	OMIM: 600749 MGI: 103572 HomoloGene: 1367 GeneCards: CEBPE Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • protein homodimerization activity • sequence-specific DNA binding • protein heterodimerization activity Cellular component • nucleus • nucleolus Biological process • phagocytosis • defense response • myeloid cell differentiation • macrophage differentiation • cytokine biosynthetic process • defense response to bacterium Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1053	110794
Ensembl	ENSG00000092067	ENSMUSG00000052435
UniProt	Q15744	Q32MW8
RefSeq (mRNA)	NM_001805	NM_207131.1
RefSeq (protein)	NP_001796	NP_997014.1
Location (UCSC)	Chr 14: 23.59 – 23.59 Mb	Chr 14: 55.33 – 55.33 Mb
PubMed search	[1]	[2]

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CHOP, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene. It is pro-apoptotic.

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.

Further reading

• Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression.". Curr. Opin. Genet. Dev. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120. 
• Gombart AF, Koeffler HP (2002). "Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon).". Curr. Opin. Hematol. 9 (1): 36–42. doi:10.1097/00062752-200201000-00007. PMID 11753076. 
• Williams SC, Cantwell CA, Johnson PF (1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.". Genes Dev. 5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID 1884998. 
• Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus.". Genomics 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101. 
• Chumakov AM, Grillier I, Chumakova E, et al. (1997). "Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor.". Mol. Cell. Biol. 17 (3): 1375–86. PMC 231862. PMID 9032264. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231862. 
• Yamanaka R, Kim GD, Radomska HS, et al. (1997). "CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing.". Proc. Natl. Acad. Sci. U.S.A. 94 (12): 6462–7. doi:10.1073/pnas.94.12.6462. PMC 21072. PMID 9177240. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21072. 
• Verbeek W, Gombart AF, Chumakov AM, et al. (1999). "C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters.". Blood 93 (10): 3327–37. PMID 10233885. 
• Lekstrom-Himes JA, Dorman SE, Kopar P, et al. (1999). "Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon.". J. Exp. Med. 189 (11): 1847–52. doi:10.1084/jem.189.11.1847. PMC 2193089. PMID 10359588. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193089. 
• Tavor S, Vuong PT, Park DJ, et al. (2002). "Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice.". Blood 99 (5): 1794–801. doi:10.1182/blood.V99.5.1794. PMID 11861297. 
• Zhang P, Nelson E, Radomska HS, et al. (2002). "Induction of granulocytic differentiation by 2 pathways.". Blood 99 (12): 4406–12. doi:10.1182/blood.V99.12.4406. PMID 12036869. 
• Kim J, Cantwell CA, Johnson PF, et al. (2002). "Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation.". J. Biol. Chem. 277 (41): 38037–44. doi:10.1074/jbc.M207235200. PMID 12161447. 
• Du J, Stankiewicz MJ, Liu Y, et al. (2003). "Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein.". J. Biol. Chem. 277 (45): 43481–94. doi:10.1074/jbc.M204777200. PMID 12202480. 
• Truong BT, Lee YJ, Lodie TA, et al. (2003). "CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia.". Blood 101 (3): 1141–8. doi:10.1182/blood-2002-05-1374. PMID 12393450. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gombart AF, Kwok SH, Anderson KL, et al. (2003). "Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1.". Blood 101 (8): 3265–73. doi:10.1182/blood-2002-04-1039. PMID 12515729. 
• Khanna-Gupta A, Zibello T, Sun H, et al. (2003). "Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression.". Blood 101 (9): 3460–8. doi:10.1182/blood-2002-09-2767. PMID 12522000. 
• Gery S, Gombart AF, Fung YK, Koeffler HP (2004). "C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis.". Blood 103 (3): 828–35. doi:10.1182/blood-2003-01-0159. PMID 12947005. 
• Gery S, Park DJ, Vuong PT, et al. (2005). "Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes.". Blood 104 (13): 3911–7. doi:10.1182/blood-2003-10-3688. PMID 15308577. 

External links

• MeSH CEBPE protein, human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.