ELF4

E74-like factor 4 (ets domain transcription factor)
Identifiers
Symbols	ELF4; ELFR; MEF
External IDs	OMIM: 300775 MGI: 1928377 HomoloGene: 31036 GeneCards: ELF4 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding Cellular component • nucleus • PML body Biological process • natural killer cell proliferation • NK T cell proliferation • transcription, DNA-dependent • regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2000	56501
Ensembl	ENSG00000102034	ENSMUSG00000031103
UniProt	Q99607	Q32MF0
RefSeq (mRNA)	NM_001127197.1	NM_019680.2
RefSeq (protein)	NP_001120669.1	NP_062654.2
Location (UCSC)	Chr X: 129.2 – 129.24 Mb	Chr X: 45.76 – 45.82 Mb
PubMed search	[1]	[2]

ETS-related transcription factor Elf-4 is a protein that in humans is encoded by the ELF4 gene.

Further reading

• Liu Y, Hedvat CV, Mao S et al. (2006). "The ETS Protein MEF Is Regulated by Phosphorylation-Dependent Proteolysis via the Protein-Ubiquitin Ligase SCFSkp2". Mol. Cell. Biol. 26 (8): 3114–23. doi:10.1128/MCB.26.8.3114-3123.2006. PMC 1446966. PMID 16581786. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1446966. 
• Moore SD, Offor O, Ferry JA et al. (2007). "ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)". Leuk. Res. 30 (8): 1037–42. doi:10.1016/j.leukres.2005.10.014. PMID 16303180. 
• Ross MT, Grafham DV, Coffey AJ et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665286. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Lu Z, Kim KA, Suico MA et al. (2004). "MEF up-regulates human beta-defensin 2 expression in epithelial cells". FEBS Lett. 561 (1–3): 117–21. doi:10.1016/S0014-5793(04)00138-3. PMID 15013761. 
• Suico MA, Yoshida H, Seki Y et al. (2004). "Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein". J. Biol. Chem. 279 (18): 19091–8. doi:10.1074/jbc.M312439200. PMID 14976184. 
• Cho JY, Akbarali Y, Zerbini LF et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". J. Biol. Chem. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218. 
• Hedvat CV, Yao J, Sokolic RA, Nimer SD (2004). "Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells". J. Biol. Chem. 279 (8): 6395–400. doi:10.1074/jbc.M307524200. PMID 14625302. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Suico MA, Koyanagi T, Ise S et al. (2002). "Functional dissection of the ETS transcription factor MEF". Biochim. Biophys. Acta 1577 (1): 113–20. PMID 12151102. 
• Mao S, Frank RC, Zhang J et al. (1999). "Functional and Physical Interactions between AML1 Proteins and an ETS Protein, MEF: Implications for the Pathogenesis of t(8;21)-Positive Leukemias". Mol. Cell. Biol. 19 (5): 3635–44. PMC 84165. PMID 10207087. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84165. 
• Aryee DN, Petermann R, Kos K et al. (1998). "Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1". Gene 210 (1): 71–8. doi:10.1016/S0378-1119(98)00022-5. PMID 9524226. 

External links

• MeSH ELF4+protein,+human