NFATC2

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
PDB rendering based on 1a02.
Available structures PDB 1A02, 1OWR, 1P7H, 1PZU, 1S9K, 2AS5, 2O93
Identifiers
Symbols	NFATC2; NFAT1; NFATP
External IDs	OMIM: 600490 MGI: 102463 HomoloGene: 7861 GeneCards: NFATC2 Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding Cellular component • nucleus • nucleus • nucleolus • cytoplasm • cytosol • plasma membrane • actin cytoskeleton Biological process • cytokine production • transcription, DNA-dependent • regulation of transcription, DNA-dependent • response to DNA damage stimulus • positive regulation of B cell proliferation • response to drug • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • B cell receptor signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4773	18019
Ensembl	ENSG00000101096	ENSMUSG00000027544
UniProt	Q13469	Q6P3F6
RefSeq (mRNA)	NM_001136021.1	NM_001037177
RefSeq (protein)	NP_001129493.1	NP_001032254
Location (UCSC)	Chr 20: 50 – 50.18 Mb	Chr 2: 168.3 – 168.43 Mb
PubMed search	[1]	[2]

Nuclear factor of activated T-cells, cytoplasmic 2 is a protein that in humans is encoded by the NFATC2 gene.

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
NFAT transcription factors are implicated in breast cancer, more specifically in the process of cell motility at the basis of metastasis formation. Indeed NFAT1 (NFATC2) is pro-invasive and pro-migratory in breast carcinoma

Interactions

NFATC2 has been shown to interact with MEF2D, EP300, IRF4 and Protein kinase Mζ.

See also

• NFAT

Further reading

• Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function". Annu. Rev. Immunol. 15: 707–747. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705. 
• Crabtree GR (1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell 96 (5): 611–614. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876. 
• Horsley V, Pavlath GK (2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation". J. Cell Biol. 156 (5): 771–774. doi:10.1083/jcb.200111073. PMC 2173310. PMID 11877454. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173310. 
• Aramburu J, Azzoni L, Rao A, Perussia B (1995). "Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding". J. Exp. Med. 182 (3): 801–810. doi:10.1084/jem.182.3.801. PMC 2192167. PMID 7650486. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2192167. 
• Auffray C, Behar G, Bois F et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816. 
• Li X, Ho SN, Luna J et al. (1995). "Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp". Cytogenet. Cell Genet. 68 (3–4): 185–191. doi:10.1159/000133910. PMID 7842733. 
• Ho S, Timmerman L, Northrop J, Crabtree GR (1995). "Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT". Adv. Exp. Med. Biol. 365: 167–73. PMID 7887301. 
• Jabado N, Le Deist F, Fisher A, Hivroz C (1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". Eur. J. Immunol. 24 (11): 2646–2652. doi:10.1002/eji.1830241112. PMID 7957556. 
• Vacca A, Farina M, Maroder M et al. (1995). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochem. Biophys. Res. Commun. 205 (1): 467–474. doi:10.1006/bbrc.1994.2689. PMID 7999066. 
• Jain J, McCaffrey PG, Miner Z et al. (1993). "The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun". Nature 365 (6444): 352–355. doi:10.1038/365352a0. PMID 8397339. 
• Luo C, Burgeon E, Carew JA et al. (1996). "Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes". Mol. Cell. Biol. 16 (7): 3955–66. PMC 231392. PMID 8668213. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231392. 
• Di Somma MM, Majolini MB, Burastero SE et al. (1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". Eur. J. Immunol. 26 (9): 2181–2188. doi:10.1002/eji.1830260933. PMID 8814265. 
• Copeland KF, McKay PJ, Rosenthal KL (1996). "Suppression of the human immunodeficiency virus long terminal repeat by CD8+ T cells is dependent on the NFAT-1 element". AIDS Res. Hum. Retroviruses 12 (2): 143–148. doi:10.1089/aid.1996.12.143. PMID 8834464. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Hodge MR, Chun HJ, Rengarajan J et al. (1997). "NF-AT-Driven interleukin-4 transcription potentiated by NIP45". Science 274 (5294): 1903–1905. doi:10.1126/science.274.5294.1903. PMID 8943202. 
• Lyakh L, Ghosh P, Rice NR (1997). "Expression of NFAT-family proteins in normal human T cells". Mol. Cell. Biol. 17 (5): 2475–84. PMC 232096. PMID 9111316. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232096. 
• Amasaki Y, Masuda ES, Imamura R et al. (1998). "Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets". J. Immunol. 160 (5): 2324–33. PMID 9498773. 
• Chen L, Glover JN, Hogan PG et al. (1998). "Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA". Nature 392 (6671): 42–48. doi:10.1038/32100. PMID 9510247. 

External links

• MeSH NFATC2+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.