NFIX

Nuclear factor I/X (CCAAT-binding transcription factor)
Identifiers
Symbols	NFIX; NF1A
External IDs	OMIM: 164005 MGI: 97311 HomoloGene: 1872 GeneCards: NFIX Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • sequence-specific enhancer binding RNA polymerase II transcription factor activity Cellular component • intracellular • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • DNA replication • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4784	18032
Ensembl	ENSG00000008441	ENSMUSG00000001911
UniProt	Q14938	P70257
RefSeq (mRNA)	NM_002501	NM_001081981
RefSeq (protein)	NP_002492	NP_001075450
Location (UCSC)	Chr 19: 13.11 – 13.21 Mb	Chr 8: 87.22 – 87.32 Mb
PubMed search	[1]	[2]

Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene.

Interactions

NFIX has been shown to interact with SKI protein.

Further reading

• Apt D, Liu Y, Bernard HU (1994). "Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner.". Nucleic Acids Res. 22 (19): 3825–33. doi:10.1093/nar/22.19.3825. PMC 308376. PMID 7937100. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=308376. 
• Sumner C, Shinohara T, Durham L, et al. (1996). "Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes.". J. Neurovirol. 2 (2): 87–100. doi:10.3109/13550289609146542. PMID 8799200. 
• Wendler WM, Kremmer E, Förster R, Winnacker EL (1997). "Identification of pirin, a novel highly conserved nuclear protein.". J. Biol. Chem. 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676. 
• Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing.". J. Biol. Chem. 272 (16): 10739–45. doi:10.1074/jbc.272.16.10739. PMID 9099724. 
• Tarapore P, Richmond C, Zheng G, et al. (1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI.". Nucleic Acids Res. 25 (19): 3895–903. doi:10.1093/nar/25.19.3895. PMC 146989. PMID 9380514. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146989. 
• Müller K, Mermod N (2000). "The histone-interacting domain of nuclear factor I activates simian virus 40 DNA replication in vivo.". J. Biol. Chem. 275 (3): 1645–50. doi:10.1074/jbc.275.3.1645. PMID 10636857. 
• Nakazato M, Chung HK, Ulianich L, et al. (2000). "Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression.". Mol. Cell. Biol. 20 (22): 8499–512. doi:10.1128/MCB.20.22.8499-8512.2000. PMC 102156. PMID 11046146. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102156. 
• Imagawa M, Sakaue R, Tanabe A, et al. (2000). "Two nuclear localization signals are required for nuclear translocation of nuclear factor 1-A.". FEBS Lett. 484 (2): 118–24. doi:10.1016/S0014-5793(00)02119-0. PMID 11068044. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Norquay LD, Yang X, Sheppard P, et al. (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin.". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117. 
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. 
• Gopalan SM, Wilczynska KM, Konik BS, et al. (2006). "Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes.". J. Biol. Chem. 281 (19): 13126–33. doi:10.1074/jbc.M601194200. PMID 16565071. 
• Ravichandran V, Sabath BF, Jensen PN, et al. (2006). "Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism.". J. Virol. 80 (21): 10506–13. doi:10.1128/JVI.01355-06. PMC 1641797. PMID 16928756. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1641797. 

External links

• MeSH NFIX+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.