HOXB5

Homeobox B5
PDB rendering based on 1hom.
Available structures PDB 1hom, 1san
Identifiers
Symbols	HOXB5; HHO.C10; HOX2; HOX2A; HU-1; Hox2.1
External IDs	OMIM: 142960 MGI: 96186 HomoloGene: 37585 GeneCards: HOXB5 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleus Biological process • multicellular organismal development • anatomical structure morphogenesis • anterior/posterior pattern formation • endothelial cell differentiation • embryonic skeletal system morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3215	15413
Ensembl	ENSG00000120075	ENSMUSG00000038700
UniProt	P09067	Q9CZV0
RefSeq (mRNA)	NM_002147	NM_008268.2
RefSeq (protein)	NP_002138	NP_032294.2
Location (UCSC)	Chr 17: 46.67 – 46.67 Mb	Chr 11: 96.16 – 96.17 Mb
PubMed search	[1]	[2]

Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.

See also

• Homeobox

Further reading

• Galang CK, Hauser CA (1992). "Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product.". New Biol. 4 (5): 558–68. PMID 1355360. 
• Peverali FA, D'Esposito M, Acampora D, et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366. 
• Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724. 
• Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=335308. 
• Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652. 
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1987). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104–8. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=387083. 
• Hart CP, Awgulewitsch A, Fainsod A, et al. (1986). "Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus.". Cell 43 (1): 9–18. doi:10.1016/0092-8674(85)90007-8. PMID 3000607. 
• Xu WM, Gorman PA, Rider SH, et al. (1988). "Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer.". Proc. Natl. Acad. Sci. U.S.A. 85 (22): 8563–7. doi:10.1073/pnas.85.22.8563. PMC 282499. PMID 3186746. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=282499. 
• Simeone A, Mavilio F, Bottero L, et al. (1986). "A human homoeo box gene specifically expressed in spinal cord during embryonic development.". Nature 320 (6064): 763–5. doi:10.1038/320763a0. PMID 3453105. 
• Hauser CA, Joyner AL, Klein RD, et al. (1986). "Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.". Cell 43 (1): 19–28. doi:10.1016/0092-8674(85)90008-X. PMID 4075393. 
• Levine M, Rubin GM, Tjian R (1984). "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.". Cell 38 (3): 667–73. doi:10.1016/0092-8674(84)90261-7. PMID 6091895. 
• Galang CK, Hauser CA (1993). "Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro.". Mol. Cell. Biol. 13 (8): 4609–17. PMC 360087. PMID 8101633. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=360087. 
• Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877. 
• Kuliev A, Kukharenko V, Morozov G, et al. (1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies.". J. Assist. Reprod. Genet. 13 (2): 177–81. doi:10.1007/BF02072541. PMID 8688592. 
• Sakach M, Safaei R (1997). "Localization of the HoxB5 protein in the developing CNS of late gestational mouse embryos.". Int. J. Dev. Neurosci. 14 (5): 567–73. doi:10.1016/0736-5748(96)00052-4. PMID 8930688. 
• Archavachotikul K, Ciccone TJ, Chinoy MR, et al. (2002). "Thyroid hormone affects embryonic mouse lung branching morphogenesis and cellular differentiation.". Am. J. Physiol. Lung Cell Mol. Physiol. 282 (3): L359–69. doi:10.1203/00006450-199904020-00286. PMID 11839528. 
• Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 

External links

• MeSH HOXB5+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.