PIAS3
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Protein inhibitor of activated STAT, 3
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| Identifiers | |||||||
| Symbols | PIAS3; FLJ14651; ZMIZ5 | ||||||
| External IDs | OMIM: 605987 MGI: 1913126 HomoloGene: 4447 | ||||||
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| RNA expression pattern | |||||||
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| Orthologs | |||||||
| Human | Mouse | ||||||
| Entrez | 10401 | 229615 | |||||
| Ensembl | ENSG00000131788 | ENSMUSG00000028101 | |||||
| Uniprot | Q9Y6X2 | Q3TM95 | |||||
| Refseq | NM_006099 (mRNA) NP_006090 (protein) |
XM_925720 (mRNA) XP_930813 (protein) |
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| Location | Chr 1: 144.29 - 144.3 Mb | Chr 3: 96.78 - 96.79 Mb | |||||
| Pubmed search | [1] | [2] |
Protein inhibitor of activated STAT, 3, also known as PIAS3, is a human gene.[1]
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.[1]
[edit] References
[edit] Further reading
- Chung CD, Liao J, Liu B, et al. (1997). "Specific inhibition of Stat3 signal transduction by PIAS3.". Science 278 (5344): 1803–5. PMID 9388184.
- Ueki N, Seki N, Yano K, et al. (1999). "Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3).". J. Hum. Genet. 44 (3): 193–6. PMID 10319586.
- Rödel B, Tavassoli K, Karsunky H, et al. (2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3.". EMBO J. 19 (21): 5845–55. doi:. PMID 11060035.
- Junicho A, Matsuda T, Yamamoto T, et al. (2001). "Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells.". Biochem. Biophys. Res. Commun. 278 (1): 9–13. doi:. PMID 11071847.
- Kotaja N, Aittomäki S, Silvennoinen O, et al. (2001). "ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation.". Mol. Endocrinol. 14 (12): 1986–2000. PMID 11117529.
- Zentner MD, Lin HH, Deng HT, et al. (2001). "Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of epithelial Na+ channel (alpha-ENaC) transcription by Ras activation in salivary epithelial cells.". J. Biol. Chem. 276 (32): 29805–14. doi:. PMID 11390395.
- Wang LH, Yang XY, Mihalic K, et al. (2001). "Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3.". J. Biol. Chem. 276 (34): 31839–44. doi:. PMID 11429412.
- Levy C, Nechushtan H, Razin E (2002). "A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia transcription factor.". J. Biol. Chem. 277 (3): 1962–6. doi:. PMID 11709556.
- Jiménez-Lara AM, Heine MJ, Gronemeyer H (2002). "PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2.". FEBS Lett. 526 (1-3): 142–6. PMID 12208521.
- Nakagawa K, Yokosawa H (2002). "PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1.". FEBS Lett. 530 (1-3): 204–8. PMID 12387893.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Yamamoto T, Sato N, Sekine Y, et al. (2003). "Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor.". Biochem. Biophys. Res. Commun. 306 (2): 610–5. PMID 12804609.
- Di Y, Li J, Zhang Y, et al. (2004). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins.". J. Biochem. 133 (6): 713–8. PMID 12869526.
- Cheng J, Zhang D, Zhou C, Marasco WA (2004). "Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells.". Leuk. Res. 28 (1): 71–82. PMID 14630083.
- Long J, Wang G, Matsuura I, et al. (2004). "Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3).". Proc. Natl. Acad. Sci. U.S.A. 101 (1): 99–104. doi:. PMID 14691252.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:. PMID 14702039.
- Nojiri S, Joh T, Miura Y, et al. (2004). "ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3.". Biochem. Biophys. Res. Commun. 314 (1): 97–103. PMID 14715251.
- Wang L, Banerjee S (2004). "Differential PIAS3 expression in human malignancy.". Oncol. Rep. 11 (6): 1319–24. PMID 15138572.
- Jang HD, Yoon K, Shin YJ, et al. (2004). "PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit.". J. Biol. Chem. 279 (23): 24873–80. doi:. PMID 15140884.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:. PMID 15231748.
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