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From Wikipedia, the free encyclopedia
| Hairy and enhancer of split 6 (Drosophila) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||
| Symbols | HES6; HES-6; bHLHb41; bHLHc23 | |||||||
| External IDs | OMIM: 610331 MGI: 1859852 HomoloGene: 23111 GeneCards: HES6 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 55502 | 55927 | ||||||
| Ensembl | ENSG00000144485 | ENSMUSG00000067071 | ||||||
| UniProt | Q96HZ4 | Q9JHE6 | ||||||
| RefSeq (mRNA) | NM_001142853.1 | NM_019479.3 | ||||||
| RefSeq (protein) | NP_001136325.1 | NP_062352.1 | ||||||
| Location (UCSC) | Chr 2: 239.15 – 239.15 Mb |
Chr 1: 93.31 – 93.31 Mb |
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| PubMed search | [1] | [2] |
Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.[1][2]
Contents |
[edit] Interactions
HES6 has been shown to interact with TLE1.[3]
[edit] References
- ^ Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development 127 (13): 2933–43. PMID 10851137.
- ^ "Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55502.
- ^ Gao, X; Chandra T, Gratton M O, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep. 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. (United States) 154 (6): 1161–71. doi:10.1083/jcb.200104058. ISSN 0021-9525. PMC 2150829. PMID 11551980. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150829.
[edit] Further reading
- Bech P, Bolwig TG, Dein E, et al. (1975). "Quantitative rating of manic states. Correlation between clinical assessment and Biegel's Objective Rating Scale.". Acta Psychiatrica Scandinavica 52 (1): 1–6. doi:10.1111/j.1600-0447.1975.tb00017.x. PMID 1155198.
- Vasiliauskas D, Stern CD (2001). "Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors.". Mech. Dev. 98 (1-2): 133–7. doi:10.1016/S0925-4773(00)00443-3. PMID 11044617.
- Gao X, Chandra T, Gratton MO, et al. (2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program.". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150829.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Swearingen ML, Sun D, Bourner M, Weinstein EJ (2003). "Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array.". Cancer Lett. 198 (2): 229–39. doi:10.1016/S0304-3835(03)00313-6. PMID 12957362.
- Gratton MO, Torban E, Jasmin SB, et al. (2003). "Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.". Mol. Cell. Biol. 23 (19): 6922–35. doi:10.1128/MCB.23.19.6922-6935.2003. PMC 193938. PMID 12972610. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=193938.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Kang SA, Seol JH, Kim J (2005). "The conserved WRPW motif of Hes6 mediates proteasomal degradation.". Biochem. Biophys. Res. Commun. 332 (1): 33–6. doi:10.1016/j.bbrc.2005.04.089. PMID 15896295.
- Ball AJ, Abrahamsson AE, Tyrberg B, et al. (2007). "HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion.". Biochem. Biophys. Res. Commun. 355 (2): 331–7. doi:10.1016/j.bbrc.2007.01.153. PMC 1852427. PMID 17300753. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1852427.
- Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D (2007). "Impaired expression of Notch signaling genes in aged human skeletal muscle.". J. Gerontol. A Biol. Sci. Med. Sci. 62 (1): 9–17. PMID 17301032.
- Scheffer D, Sage C, Corey DP, Pingault V (2007). "Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells.". FEBS Lett. 581 (24): 4651–6. doi:10.1016/j.febslet.2007.08.059. PMID 17826772.
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