SLC10A2

Solute carrier family 10 (sodium/bile acid cotransporter family), member 2
Identifiers
Symbols	SLC10A2; ASBT; IBAT; ISBT; NTCP2; PBAM
External IDs	OMIM: 601295 MGI: 1201406 HomoloGene: 390 GeneCards: SLC10A2 Gene
Gene Ontology Molecular function • bile acid:sodium symporter activity • symporter activity Cellular component • proteasome complex • nucleus • plasma membrane • integral to plasma membrane • apical plasma membrane Biological process • transport • ion transport • sodium ion transport • bile acid metabolic process • organic anion transport • bile acid and bile salt transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6555	20494
Ensembl	ENSG00000125255	ENSMUSG00000023073
UniProt	Q12908	Q0VBB8
RefSeq (mRNA)	NM_000452	NM_011388.2
RefSeq (protein)	NP_000443	NP_035518.1
Location (UCSC)	Chr 13: 103.7 – 103.72 Mb	Chr 8: 5.09 – 5.11 Mb
PubMed search	[1]	[2]

Ileal sodium/bile acid cotransporter also known as ileal sodium-dependent bile acid transporter (ISBT or IBAT) is a protein that in humans is encoded by the SLC10A2 (solute carrier family 10 member 2) gene.

See also

• Solute carrier family

Further reading

• Shneider BL (2001). "Intestinal bile acid transport: biology, physiology, and pathophysiology.". J. Pediatr. Gastroenterol. Nutr. 32 (4): 407–17. doi:10.1097/00005176-200104000-00002. PMID 11396803. 
• Balakrishnan A, Polli JE (2006). "Apical Sodium Dependent Bile Acid Transporter (ASBT, SLC10A2): A Potential Prodrug Target". Mol. Pharm. 3 (3): 223–30. doi:10.1021/mp060022d. PMC 2796132. PMID 16749855. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2796132. 
• Wong MH, Oelkers P, Dawson PA (1995). "Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity". J. Biol. Chem. 270 (45): 27228–34. doi:10.1074/jbc.270.45.27228. PMID 7592981. 
• Oelkers P, Kirby LC, Heubi JE, Dawson PA (1997). "Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)". J. Clin. Invest. 99 (8): 1880–7. doi:10.1172/JCI119355. PMC 508012. PMID 9109432. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=508012. 
• Craddock AL, Love MW, Daniel RW et al. (1998). "Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter". Am. J. Physiol. 274 (1 Pt 1): G157–69. PMID 9458785. 
• Montagnani M, Love MW, Rössel P et al. (2002). "Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption". Scand. J. Gastroenterol. 36 (10): 1077–80. doi:10.1080/003655201750422693. PMID 11589382. 
• Love MW, Craddock AL, Angelin B et al. (2002). "Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia". Arterioscler. Thromb. Vasc. Biol. 21 (12): 2039–45. doi:10.1161/hq1201.100262. PMID 11742882. 
• Jung D, Fried M, Kullak-Ublick GA (2002). "Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha". J. Biol. Chem. 277 (34): 30559–66. doi:10.1074/jbc.M203511200. PMID 12055195. 
• Zelcer N, Saeki T, Bot I et al. (2003). "Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter". Biochem. J. 369 (Pt 1): 23–30. doi:10.1042/BJ20021081. PMC 1223054. PMID 12220224. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223054. 
• Chumakov I, Blumenfeld M, Guerassimenko O et al. (2002). "Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13675–80. doi:10.1073/pnas.182412499. PMC 129739. PMID 12364586. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129739. 
• Dunham A, Matthews LH, Burton J et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665288. 
• Neimark E, Chen F, Li X, Shneider BL (2004). "Bile acid-induced negative feedback regulation of the human ileal bile acid transporter". Hepatology 40 (1): 149–56. doi:10.1002/hep.20295. PMID 15239098. 
• Xia X, Roundtree M, Merikhi A et al. (2004). "Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes". J. Biol. Chem. 279 (43): 44931–7. doi:10.1074/jbc.M400969200. PMID 15304498. 
• Zhang EY, Phelps MA, Banerjee A et al. (2004). "Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2)". Biochemistry 43 (36): 11380–92. doi:10.1021/bi049270a. PMID 15350125. 
• Banerjee A, Ray A, Chang C, Swaan PW (2005). "Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2)". Biochemistry 44 (24): 8908–17. doi:10.1021/bi050553s. PMID 15952798. 
• Nakahara M, Furuya N, Takagaki K et al. (2006). "Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine". J. Biol. Chem. 280 (51): 42283–9. doi:10.1074/jbc.M507454200. PMID 16230354. 
• Bergheim I, Harsch S, Mueller O et al. (2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers". J. Lipid Res. 47 (1): 42–50. doi:10.1194/jlr.M500215-JLR200. PMID 16237211. 
• Banerjee A, Swaan PW (2006). "Membrane Topology Of Human ASBT (SLC10A2) Determined By Dual Label Epitope Insertion Scanning Mutagenesis. New Evidence For Seven Transmembrane Domains". Biochemistry 45 (3): 943–53. doi:10.1021/bi052202j. PMC 2525805. PMID 16411770. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2525805. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.