Iproclozide

Iproclozide
Systematic (IUPAC) name
	2-(4-chlorophenoxy)-N'-isopropyl-acetohydrazide
Clinical data
Pregnancy cat.	?
Legal status	Uncontrolled
Routes	Oral
Identifiers
CAS number	3544-35-2
ATC code	N06AF06
PubChem	CID 19063
ChemSpider	17998
UNII	1II9D6CB3J
KEGG	D07338
ChEMBL	CHEMBL91238
Chemical data
Formula	C11H15ClN2O2
Mol. mass	242.70 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C11H15ClN2O2/c1-8(2)13-14-11(15)7-16-10-5-3-9(12)4-6-10/h3-6,8,13H,7H2,1-2H3,(H,14,15) ; Key:GGECDTUJZOXAAR-UHFFFAOYSA-N ;
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Iproclozide (trade names Sursum, Sinderesin) is an irreversible and selective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant, but has since been discontinued.^[1] It has been known to cause fulminant hepatitis and there have been at least three reported fatalities due to administration of the drug.^[2]^[3]

[edit] See also

^ Suerinck A, Suerinck E. (1966). "[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]". J Med Lyon. 47 (96): 573–586. PMID 5930723.
^ Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP. (1978). "Iproclozide fulminant hepatitis. Possible role of enzyme induction.". Gastroenterology. 75 (3): 492–496. PMID 680506.
^ Neil Kaplowitz, Laurie D. DeLeve (2003). Drug-induced liver disease. Informa Health Care. p. 455. ISBN 0824708113, 9780824708115.

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