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Pargyline

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Pargyline
Systematic (IUPAC) name
N-Benzyl-N-methylprop-2-yn-1-amine
Clinical data
MedlinePlus a682088
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 555-57-7 YesY
ATC code C02KC01 C02LL01
PubChem CID 4688
DrugBank DB01626
ChemSpider 4526 YesY
UNII 9MV14S8G3E YesY
ChEMBL CHEMBL673 YesY
Chemical data
Formula C11H13N 
Mol. mass 159.23 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Pargyline (Eutonyl) is an irreversible monoamine oxidase B (MAO-B) inhibitor.[1] It has antihypertensive effects.[2]

[edit] Pharmacology

It functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as blue cheese and beer, as this can lead to a hypertensive crisis.[3]

[edit] References

  1. ^ Murphy DL, Karoum F, Pickar D, et al. (1998). "Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)". J. Neural Transm. Suppl. 52: 39–48. PMID 9564606. 
  2. ^ Fuentes JA, Ordaz A, Neff NH (July 1979). "Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats". Eur. J. Pharmacol. 57 (1): 21–7. doi:10.1016/0014-2999(79)90099-2. PMID 477738. 
  3. ^ Tulane University School of Medicine Department of Pharmacology: Autonomic Drug Profile handout, October 2006



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