Mefway (¹⁸F)

Mefway (¹⁸F)
Systematic (IUPAC) name
	4-[(18F)fluoromethyl]-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexane-1-carboxamide
Clinical data
Pregnancy cat.	N/A
Legal status	Research compound
Identifiers
ATC code	None
PubChem	CID 11963740
ChemSpider	10137857
Chemical data
Formula	C26H35FN4O2
Mol. mass	453.583 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C26H35FN4O2/c1-33-24-7-3-2-6-23(24)30-17-14-29(15-18-30)16-19-31(25-8-4-5-13-28-25)26(32)22-11-9-21(20-27)10-12-22/h2-8,13,21-22H,9-12,14-20H2,1H3/i27-1; Key:BQGLPDFQLBNUGU-FMLNDMEQSA-N;

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Mefway is a 5-HT_1A receptor antagonist used in medical research, usually in the form of mefway (¹⁸F) as a positron emission tomography (PET) radiotracer.^[1] It is closely related to the research compound WAY-100,635. There are two stereoisomers with regard to the cyclohexane ring, of which the trans configuration has the higher 5-HT_1A specifity.^[1]

[edit] References

^ ^a ^b Wooten, D.; Hillmer, A.; Murali, D.; Barnhart, T.; Schneider, M. L.; Mukherjee, J.; Christian, B. T. (2011). "An in vivo comparison of cis- and trans-[18F]mefway in the nonhuman primate". Nuclear Medicine and Biology. doi:10.1016/j.nucmedbio.2011.04.001. PMID 21741252. edit


Systematic (IUPAC) name
4-[(¹⁸F)fluoromethyl]-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexane-1-carboxamide
Clinical data
Pregnancy cat.	N/A
Legal status	Research compound
Identifiers
ATC code	None
PubChem	CID 11963740
ChemSpider	10137857
Chemical data
Formula	C₂₆H₃₅F N₄O₂
Mol. mass	453.583 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C26H35FN4O2/c1-33-24-7-3-2-6-23(24)30-17-14-29(15-18-30)16-19-31(25-8-4-5-13-28-25)26(32)22-11-9-21(20-27)10-12-22/h2-8,13,21-22H,9-12,14-20H2,1H3/i27-1 Key:BQGLPDFQLBNUGU-FMLNDMEQSA-N