FZD10

Frizzled family receptor 10
Identifiers
Symbols	FZD10; CD350; FZ-10; Fz10; FzE7; hFz10
External IDs	OMIM: 606147 MGI: 2136761 HomoloGene: 21411 IUPHAR: FZD10 GeneCards: FZD10 Gene
Gene Ontology
Molecular function	• G-protein coupled receptor activity; • protein binding; • Wnt-protein binding; • PDZ domain binding; • Wnt receptor activity;
Cellular component	• cytoplasm; • plasma membrane; • integral to plasma membrane; • cell surface; • cell projection;
Biological process	• vasculature development; • brain development; • gonad development; • embryo development; • neuron differentiation; • positive regulation of Rac GTPase activity; • regulation of actin cytoskeleton organization; • negative regulation of Rho GTPase activity; • non-canonical Wnt receptor signaling pathway; • positive regulation of JUN kinase activity; • canonical Wnt receptor signaling pathway; • cellular response to retinoic acid;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Frizzled-10 is a protein that in humans is encoded by the FZD10 gene.^[1]^[2] FZD10 has also been designated as CD350 (cluster of differentiation 350).

This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.^[2]

[edit] See also

Frizzled

[edit] References

^ Koike J, Takagi A, Miwa T, Hirai M, Terada M, Katoh M (Sep 1999). "Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family". Biochem Biophys Res Commun 262 (1): 39–43. doi:10.1006/bbrc.1999.1161. PMID 10448064.
^ ^a ^b "Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11211.

[edit] Further reading

Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21233.
Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21479.
Kumar S, Connor JR, Dodds RA, et al. (2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries". Osteoarthr. Cartil. 9 (7): 641–53. doi:10.1053/joca.2001.0421. PMID 11597177.
Terasaki H, Saitoh T, Shiokawa K, Katoh M (2002). "Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway". Int. J. Mol. Med. 9 (2): 107–12. PMID 11786918.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.

[edit] External links

"Frizzled Receptors: FZD₁₀". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3068.
MeSH FZD10+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[pmid10448064-0] Koike J, Takagi A, Miwa T, Hirai M, Terada M, Katoh M (Sep 1999). "Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family". Biochem Biophys Res Commun 262 (1): 39–43. doi:10.1006/bbrc.1999.1161. PMID 10448064.

[entrez-1] "Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11211.

[1]

[2]

Jan	FEB	Mar
	18
2011	2012	2013

FZD10

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