Butyrophenone

Butyrophenone
IUPAC name 1-phenylbutan-1-one
Identifiers
CAS number	495-40-9 Y
PubChem	10315
ChemSpider	9893 Y
ChEMBL	CHEMBL193524 Y
Jmol-3D images	Image 1 Image 2
SMILES O=C(c1ccccc1)CCC CCCC(=O)c1ccccc1
InChI InChI=1S/C10H12O/c1-2-6-10(11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3 Y Key: FFSAXUULYPJSKH-UHFFFAOYSA-N Y InChI=1/C10H12O/c1-2-6-10(11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3 Key: FFSAXUULYPJSKH-UHFFFAOYAC
Properties
Molecular formula	C10H12O
Molar mass	148.20 g/mol
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Butyrophenone is a chemical compound (with a ketone functional group); some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.

Butyrophenones are a class of pharmaceutical drugs derived from butyrophenone.

Examples include:

• Haloperidol, the most widely used classical antipsychotic drug in this class
• Droperidol, often used for neuroleptanalgesic anesthesia and sedation in intensive-care treatment
• Benperidol, the most potent commonly used antipsychotic ( 200 times more potent than chlorpromazine)
• Triperidol, a highly potent antipsychotic (100 times more potent than chlorpromazine)
• Melperone, a weakly potent antipsychotic, in Europe commonly used for treatment of insomnia, confusional states, psychomotor agitation, and delirium, in particular, in geriatric patients
• Lenperone
• Domperidone, a dopamine-antagonist antiemetic, derived further from butyrophenone (not being a butyrophenone itself).

The atypical antipsychotic risperidone, although not a butyrophenone, was developed with the structures of benperidol and lenperone as a basis.