Loreclezole
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| Systematic (IUPAC) name | |
| 1-[(Z)-2-chloro-2-(2,4-dichlorophenyl)vinyl]-1H-1,2,4-triazole | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 117857-45-1  |
| ATC code | None |
| PubChem | CID 3034012 |
| ChemSpider | 2298566 |
| UNII | 6DJ32STZ5W |
| KEGG | D04780 |
| Chemical data | |
| Formula | C10H6Cl3N3 |
| Mol. mass | 274.534 g/mol |
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Loreclezole is a sedative and an anticonvulsant which acts as a GABA agonist. It binds allosterically to the GABAA receptor.[1] The binding site of loreclezole has been shown experimentally to be shared by valerenic acid, an extract of the root of the valerian plant.[2]
[edit] References
- ^ Wingrove, P. B.; Wafford, K. A.; Bain, C.; Whiting, P. J. (1994). "The modulatory action of loreclezole at the gamma-aminobutyric acid type a receptor is determined by a single amino acid in the beta 2 and beta 3 subunit". Proceedings of the National Academy of Sciences of the United States of America 91 (10): 4569–4573. PMC 43827. PMID 8183949. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=43827.
- ^ Khom, S.; Baburin, I.; Timin, E.; Hohaus, A.; Trauner, G.; Kopp, B.; Hering, S. (2007). "Valerenic acid potentiates and inhibits GABAA receptors: Molecular mechanism and subunit specificity". Neuropharmacology 53 (1): 178–187. doi:10.1016/j.neuropharm.2007.04.018. PMID 17585957.
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