From Wikipedia, the free encyclopedia
Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene.[1][2]
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.[2]
[edit] See also
[edit] References
[edit] Further reading
- Mehta AK, Ticku MK (1999). "An update on GABAA receptors.". Brain Res. Brain Res. Rev. 29 (2-3): 196–217. doi:10.1016/S0165-0173(98)00052-6. PMID 10209232.
- Zafrakas M, Chorovicer M, Klaman I, et al. (2007). "Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue.". Int. J. Cancer 118 (6): 1453–9. doi:10.1002/ijc.21517. PMID 16187283.
- Petryshen TL, Middleton FA, Tahl AR, et al. (2006). "Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia.". Mol. Psychiatry 10 (12): 1074–88, 1057. doi:10.1038/sj.mp.4001739. PMID 16172613.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes.". J. Neurovirol. 9 (3): 358–71. doi:10.1080/713831545. PMID 12775419.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Neelands TR, Macdonald RL (1999). "Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors.". Mol. Pharmacol. 56 (3): 598–610. PMID 10462548.
- Taylor PM, Thomas P, Gorrie GH, et al. (1999). "Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression.". J. Neurosci. 19 (15): 6360–71. PMID 10414965.
[edit] External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| v · d · eIon channel, cell surface receptor: ligand-gated ion channels |
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GABAA ( α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ) · GABAA-ρ ( ρ1, ρ2, ρ3)
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Zinc
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| Ionotropic glutamates |
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Ligand-gated only
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Voltage- and ligand-gated
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‘Orphan’
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| ATP-gated channels |
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| B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp) |
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