GTF2E2

General transcription factor IIE, polypeptide 2, beta 34kDa
PDB rendering based on 1d8k.
Available structures PDB 1D8J, 1D8K
Identifiers
Symbols	GTF2E2; FE; TF2E2; TFIIE-B
External IDs	OMIM: 189964 MGI: 1915403 HomoloGene: 37573 GeneCards: GTF2E2 Gene
Gene Ontology Molecular function • DNA binding • protein binding Cellular component • nucleus • nucleoplasm • nucleoplasm • transcription factor TFIIE complex Biological process • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • gene expression • viral reproduction Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2961	68153
Ensembl	ENSG00000197265	ENSMUSG00000031585
UniProt	P29084	Q9D902
RefSeq (mRNA)	NM_002095	NM_001167922
RefSeq (protein)	NP_002086	NP_001161394
Location (UCSC)	Chr 8: 30.44 – 30.52 Mb	Chr 8: 34.84 – 34.89 Mb
PubMed search	[1]	[2]

General transcription factor IIE subunit 2 (GTF2E2), also known as transcription initiation factor IIE subunit beta (TFIIE-beta), is a protein that in humans is encoded by the GTF2E2 gene.

See also

• Transcription factor II E

Further reading

• Jeronimo C, Forget D, Bouchard A et al. (2007). "Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme". Mol. Cell 27 (2): 262–74. doi:10.1016/j.molcel.2007.06.027. PMID 17643375. 
• Tanaka A, Watanabe T, Iida Y et al. (2009). "Central forkhead domain of human TFIIE beta plays a primary role in binding double-stranded DNA at transcription initiation". Genes Cells 14 (3): 395–405. doi:10.1111/j.1365-2443.2008.01278.x. PMID 19210545. 
• Kang SW, Kuzuhara T, Horikoshi M (2000). "Functional interaction of general transcription initiation factor TFIIE with general chromatin factor SPT16/CDC68". Genes Cells 5 (4): 251–63. doi:10.1046/j.1365-2443.2000.00323.x. PMID 10792464. 
• Langelier MF, Forget D, Rojas A et al. (2001). "Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II". J. Biol. Chem. 276 (42): 38652–7. doi:10.1074/jbc.M106422200. PMID 11509574. 
• Yamamoto S, Watanabe Y, van der Spek PJ et al. (2001). "Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation". Mol. Cell. Biol. 21 (1): 1–15. doi:10.1128/MCB.21.1.1-15.2001. PMC 86563. PMID 11113176. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86563. 
• Watanabe T, Hayashi K, Tanaka A et al. (2003). "The carboxy terminus of the small subunit of TFIIE regulates the transition from transcription initiation to elongation by RNA polymerase II". Mol. Cell. Biol. 23 (8): 2914–26. PMC 152561. PMID 12665589. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=152561. 
• Jawhari A, Uhring M, De Carlo S et al. (2006). "Structure and oligomeric state of human transcription factor TFIIE". EMBO Rep. 7 (5): 500–5. doi:10.1038/sj.embor.7400663. PMC 1479554. PMID 16547462. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1479554. 
• Orphanides G, Lagrange T, Reinberg D (1996). "The general transcription factors of RNA polymerase II". Genes Dev. 10 (21): 2657–83. doi:10.1101/gad.10.21.2657. PMID 8946909. 
• Kim TK, Ebright RH, Reinberg D (2000). "Mechanism of ATP-dependent promoter melting by transcription factor IIH". Science 288 (5470): 1418–22. doi:10.1126/science.288.5470.1418. PMID 10827951. 
• Ikeda K, Halle JP, Stelzer G et al. (1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6". Mol. Cell. Biol. 18 (1): 10–8. PMC 121442. PMID 9418848. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=121442. 
• Holstege FC, Fiedler U, Timmers HT (1997). "Three transitions in the RNA polymerase II transcription complex during initiation". EMBO J. 16 (24): 7468–80. doi:10.1093/emboj/16.24.7468. PMC 1170346. PMID 9405375. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170346. 
• Cirulli ET, KasperaviciÅ«te D, Attix DK et al. (2010). "Common genetic variation and performance on standardized cognitive tests". Eur. J. Hum. Genet. 18 (7): 815–20. doi:10.1038/ejhg.2010.2. PMC 2987367. PMID 20125193. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2987367. 
• Yu X, Li P, Roeder RG, Wang Z (2001). "Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split". Mol. Cell. Biol. 21 (14): 4614–25. doi:10.1128/MCB.21.14.4614-4625.2001. PMC 87125. PMID 11416139. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87125. 
• Yokomori K, Verrijzer CP, Tjian R (1998). "An interplay between TATA box-binding protein and transcription factors IIE and IIA modulates DNA binding and transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6722–7. doi:10.1073/pnas.95.12.6722. PMC 22611. PMID 9618479. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22611. 
• Liu L, Ishihara K, Ichimura T et al. (2009). "MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity". J. Biol. Chem. 284 (8): 5165–74. doi:10.1074/jbc.M807098200. PMID 19106100. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• De Graeve F, Bahr A, Chatton B, Kedinger C (2000). "A murine ATFa-associated factor with transcriptional repressing activity". Oncogene 19 (14): 1807–19. doi:10.1038/sj.onc.1203492. PMID 10777215. 
• Okamoto T, Yamamoto S, Watanabe Y et al. (1998). "Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIEbeta subunit". J. Biol. Chem. 273 (31): 19866–76. doi:10.1074/jbc.273.31.19866. PMID 9677423. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Festen EA, Stokkers PC, van Diemen CC et al. (2010). "Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk". Am. J. Gastroenterol. 105 (2): 395–402. doi:10.1038/ajg.2009.576. PMID 19861958.