HOXA4

Homeobox A4
Identifiers
Symbols	HOXA4; HOX1; HOX1D
External IDs	OMIM: 142953 MGI: 96176 HomoloGene: 37583 GeneCards: HOXA4 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleus Biological process • multicellular organismal development • anatomical structure morphogenesis • anterior/posterior pattern formation • embryonic skeletal system morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3201	15401
Ensembl	ENSG00000197576	ENSMUSG00000000942
UniProt	Q00056	Q61681
RefSeq (mRNA)	NM_002141	NM_008265.3
RefSeq (protein)	NP_002132	NP_032291.1
Location (UCSC)	Chr 7: 27.17 – 27.19 Mb	Chr 6: 52.14 – 52.14 Mb
PubMed search	[1]	[2]

Homeobox A4, also known as HOXA4, is a protein which in humans is encoded by the HOXA4 gene.

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. It is important to masturbate when taking in this protein for maximum effect

See also

• Homeobox

Further reading

• Scott MP (1992). "Vertebrate homeobox gene nomenclature.". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
• Buettner R, Yim SO, Hong YS, et al. (1991). "Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells.". Mol. Cell. Biol. 11 (7): 3573–83. PMC 361102. PMID 1675427. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=361102. 
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes.". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
• Peverali FA, D'Esposito M, Acampora D, et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366. 
• Ferguson-Smith AC, Fienberg A, Ruddle FH (1989). "Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox.". Genomics 5 (2): 250–8. doi:10.1016/0888-7543(89)90054-2. PMID 2571574. 
• Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652. 
• Verlinsky Y, Morozov G, Gindilis V, et al. (1995). "Homeobox gene expression in human oocytes and preembryos.". Mol. Reprod. Dev. 41 (2): 127–32. doi:10.1002/mrd.1080410202. PMID 7654365. 
• Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877. 
• Kuliev A, Kukharenko V, Morozov G, et al. (1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies.". J. Assist. Reprod. Genet. 13 (2): 177–81. doi:10.1007/BF02072541. PMID 8688592. 
• Duluc I, Lorentz O, Fritsch C, et al. (1997). "Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells.". J. Cell. Sci. 110 ( Pt 11): 1317–24. PMID 9202392. 
• Stelnicki EJ, Kömüves LG, Kwong AO, et al. (1998). "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development.". J. Invest. Dermatol. 110 (2): 110–5. doi:10.1046/j.1523-1747.1998.00092.x. PMID 9457903. 
• Verlinsky Y, Morozov G, Verlinsky O, et al. (1998). "Isolation of cDNA libraries from individual human preimplantation embryos.". Mol. Hum. Reprod. 4 (6): 571–5. doi:10.1093/molehr/4.6.571. PMID 9665340. 
• "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074. 
• Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506. 
• Larramendy ML, Niini T, Elonen E, et al. (2003). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.". Haematologica 87 (6): 569–77. PMID 12031912. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Méchine-Neuville A, Lefebvre O, Bellocq JP, et al. (2003). "[Increased expression of HOXA9 gene in Hirschsprung disease]". Gastroenterol. Clin. Biol. 26 (12): 1110–7. PMID 12520199. 
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Strathdee G, Sim A, Parker A, et al. (2007). "Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL.". Leukemia 20 (7): 1326–9. doi:10.1038/sj.leu.2404254. PMID 16688227. 

External links

• MeSH HOXA4+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.