POU3F1

POU class 3 homeobox 1
Identifiers
Symbols	POU3F1; OCT6; OTF6; SCIP
External IDs	OMIM: 602479 MGI: 101896 HomoloGene: 20590 GeneCards: POU3F1 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleus • transcription factor complex Biological process • transcription, DNA-dependent • regulation of transcription, DNA-dependent • axon ensheathment • epidermis development • positive regulation of gene expression • myelination in peripheral nervous system • keratinocyte differentiation • forebrain development • positive regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5453	18991
Ensembl	ENSG00000185668	ENSMUSG00000078236
UniProt	Q03052	n/a
RefSeq (mRNA)	NM_002699	NM_011141.2
RefSeq (protein)	NP_002690	NP_035271.1
Location (UCSC)	Chr 1: 38.51 – 38.51 Mb	Chr 4: 124.33 – 124.34 Mb
PubMed search	[1]	[2]

POU domain, class 3, transcription factor 1 is a protein that in humans is encoded by the POU3F1 gene.

See also

• Octamer transcription factor

Further reading

• Monuki ES, Kuhn R, Weinmaster G, et al. (1990). "Expression and activity of the POU transcription factor SCIP.". Science 249 (4974): 1300–3. doi:10.1126/science.1975954. PMID 1975954. 
• Suzuki N, Rohdewohld H, Neuman T, et al. (1990). "Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain.". EMBO J. 9 (11): 3723–32. PMC 552128. PMID 1976514. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=552128. 
• Zwilling S, König H, Wirth T (1995). "High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors.". EMBO J. 14 (6): 1198–208. PMC 398197. PMID 7720710. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=398197. 
• Leger H, Sock E, Renner K, et al. (1995). "Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y.". Mol. Cell. Biol. 15 (7): 3738–47. PMC 230612. PMID 7791781. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230612. 
• Faus I, Hsu HJ, Fuchs E (1994). "Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia.". Mol. Cell. Biol. 14 (5): 3263–75. PMC 358693. PMID 7909356. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=358693. 
• Abdel-Rahman B, Fiddler M, Rappolee D, Pergament E (1996). "Expression of transcription regulating genes in human preimplantation embryos.". Hum. Reprod. 10 (10): 2787–92. PMID 8567814. 
• Jaegle M, Mandemakers W, Broos L, et al. (1996). "The POU factor Oct-6 and Schwann cell differentiation.". Science 273 (5274): 507–10. doi:10.1126/science.273.5274.507. PMID 8662541. 
• Sock E, Enderich J, Rosenfeld MG, Wegner M (1996). "Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6.". J. Biol. Chem. 271 (29): 17512–8. doi:10.1074/jbc.271.29.17512. PMID 8663425. 
• Malik KF, Jaffe H, Brady J, Young WS (1997). "The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.". Brain Res. Mol. Brain Res. 45 (1): 99–107. doi:10.1016/S0169-328X(96)00238-0. PMID 9105675. 
• Sumiyama K, Washio-Watanabe K, Ono T, et al. (1998). "Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2.". Mamm. Genome 9 (2): 180–1. doi:10.1007/s003359900721. PMID 9457692. 
• Arroyo EJ, Bermingham JR, Rosenfeld MG, Scherer SS (1998). "Promyelinating Schwann cells express Tst-1/SCIP/Oct-6.". J. Neurosci. 18 (19): 7891–902. PMID 9742157. 
• Kawasaki T, Oka N, Tachibana H, et al. (2003). "Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies.". Acta Neuropathol. 105 (3): 203–8. doi:10.1007/s00401-002-0630-9. PMID 12557005. 
• Beck IM, Müller M, Mentlein R, et al. (2007). "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation.". J. Invest. Dermatol. 127 (5): 1107–14. doi:10.1038/sj.jid.5700674. PMID 17195013. 
• Ryu EJ, Wang JY, Le N, et al. (2007). "Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss.". J. Neurosci. 27 (43): 11552–9. doi:10.1523/JNEUROSCI.5497-06.2007. PMID 17959798. 

External links

• MeSH POU3F1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.