GTF3C1

General transcription factor IIIC, polypeptide 1, alpha 220kDa
Identifiers
Symbols	GTF3C1; DKFZp686A111; TFIIIC; TFIIIC220; TFIIICalpha
External IDs	OMIM: 603246 MGI: 107887 HomoloGene: 31040 GeneCards: GTF3C1 Gene
Gene Ontology Molecular function • DNA binding • protein binding Cellular component • transcription factor TFIIIC complex • nucleus • nucleoplasm • ribonucleoprotein complex Biological process • transcription, DNA-dependent • transcription from RNA polymerase III promoter • rRNA transcription • tRNA transcription • 5S class rRNA transcription from RNA polymerase III type 1 promoter • tRNA transcription from RNA polymerase III promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2975	233863
Ensembl	ENSG00000077235	ENSMUSG00000032777
UniProt	Q12789	A0JLN7
RefSeq (mRNA)	NM_001520	NM_207239.1
RefSeq (protein)	NP_001511	NP_997122.1
Location (UCSC)	Chr 16: 27.47 – 27.56 Mb	Chr 7: 132.78 – 132.85 Mb
PubMed search	[1]	[2]

General transcription factor 3C polypeptide 1 is a protein that in humans is encoded by the GTF3C1 gene.

Interactions

GTF3C1 has been shown to interact with GTF3C4.

Further reading

• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC.". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646. 
• Kovelman R, Roeder RG (1992). "Purification and characterization of two forms of human transcription factor IIIC.". J. Biol. Chem. 267 (34): 24446–56. PMID 1447193. 
• Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III.". Mol. Cell 1 (5): 749–57. doi:10.1016/S1097-2765(00)80074-X. PMID 9660958. 
• Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829. 
• Hsieh YJ, Kundu TK, Wang Z, et al. (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity.". Mol. Cell. Biol. 19 (11): 7697–704. PMC 84812. PMID 10523658. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84812. 
• Meissner W, Thomae R, Seifart KH (2002). "The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells.". J. Biol. Chem. 277 (9): 7148–56. doi:10.1074/jbc.M108721200. PMID 11741993. 
• Zhan Y, Hegde R, Srinivasula SM, et al. (2002). "Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.". Cell Death Differ. 9 (4): 439–47. doi:10.1038/sj/cdd/4401038. PMID 11965497. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Weser S, Riemann J, Seifart KH, Meissner W (2003). "Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene.". Nucleic Acids Res. 31 (9): 2408–16. doi:10.1093/nar/gkg345. PMC 154231. PMID 12711686. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=154231. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Dumay-Odelot H, Marck C, Durrieu-Gaillard S, et al. (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC.". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385. 

External links

• MeSH GTF3C1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.