Wang Xiaodong
Xiaodong Wang (simplified Chinese: 王晓东; traditional Chinese: 王曉東; pinyin: Wāng Xiǎodōng, born 1963) is an American biochemist best known for his work with cytochrome c. His laboratory developed an in-vitro assay for the activation of the apoptosis related proteinase Caspase-3. This allowed the biochemical purification a complex of Cytochrome c, Caspase-9 and the Apoptotic Protease Activating factor-1 (Apaf-1). These components are essential for forming a ternary complex called the apoptosome that activates Caspase-3 downstream of the intracellular or mitochondrial pathway of apoptosis.[1]
He was awarded the 2006 Shaw Prize in Life Science and Medicine.[2]
Wang is a member of United States National Academy of Sciences and the Howard Hughes Medical Institute. Currently he is a professor at National Institute of Biological Sciences, Beijing.[3]
[edit] Honors & awards
- 2002, Hackerman Award, from the Welch Foundation
- 2001, Paul Marks Prize, from the Memorial Sloan-Kettering Cancer Center
- 2000, Eli Lilly Award, from American Chemical Society
- 2007, Richard Lounsbery Award, from the National Academy of Sciences, USA
- 2006, Shaw Prize, from the Shaw Foundation
[edit] References
- ^ "Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.Cell. 1997 Aug 8;90(3):405-13.". 1997-08-08. http://www.cell.com/abstract/S0092-8674(00)80501-2. Retrieved 2009-02-09.
- ^ "The Shaw Prize". The Shaw Prize. 2006-06-21. http://www.shawprize.org/en/laureates/2006/life/Wang/announcement.html. Retrieved 2007-08-01.
- ^ Xiaodong Wang, Ph.D. Lab Research Profile
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